Browsing Clinical Medicine (Scholarly Publications) by Subject "Clinical Medicine"
Now showing items 1-20 of 36
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The C-type lectin SIGNR1 binds Schistosoma mansoni antigens in vitro, but SIGNR1-deficient mice have normal responses during schistosome infection
(American Society for Microbiology, 2009)The de novo immune response to infectious organisms arises from the innate recognition of pathogen-associated molecular patterns (PAMPs) by the host's pattern recognition receptors (PRRs). As the generation of type 2 ... -
Characterization of signaling pathways activated by the interleukin 1 (IL-1) receptor homologue T1/ST2. A role for Jun N-terminal kinase in IL-4 induction
(American Society for Biochemistry and Molecular Biology, 2002)T1/ST2 is a member of the interleukin (IL)-1 receptor superfamily, possessing three immunoglobulin domains extracellularly and a Toll/IL1R (TIR) domain intracellularly. The ligand for T1/ST2 is not known. T1/ST2 is expressed ... -
Clinical relevance of low serum vitamin B12 concentrations in older people: the Banbury B12 study.
(Oxford University Press, 2006)BACKGROUND: low vitamin B12 concentrations are common in older people, but the clinical relevance of biochemical evidence of vitamin B12 deficiency in the absence of anaemia is uncertain. OBJECTIVE: to examine associations ... -
Coagulopathy After Cardiac Surgery May Be Influenced by a Functional Plasminogen Activator Inhibitor Polymorphism
(2007)BACKGROUND: Cytokine-mediated inflammation and coagulopathy may occur after cardiac surgery. In this study we investigated the temporal pattern of plasminogen activator inhibitor-1 (PAI-1) gene expression after cardiac ... -
A common insertion/deletion polymorphism of the thymidylate synthase (TYMS) gene is a determinant of red blood cell folate and homocysteine concentrations
(Springer, 2005)Substantial evidence suggests that a low folate/high homocysteine phenotype is pathogenic. We analyzed the impact of the thymidylate synthase (TYMS) 3UTR ins/del polymorphism on folate and homocysteine levels and assessed ... -
Conjugated linoleic acid suppresses NF-kappa B activation and IL-12 production in dendritic cells through ERK-mediated IL-10 induction
(The American Association of Immunologists, 2005)Polyunsaturated fatty acids (PUFA) have been shown to modulate immune responses and have therapeutic effects in inflammatory disorders. However, the influence of PUFA on dendritic cells (DC), key cells of the innate immune ... -
Decoy receptors in the regulation of T Helper cell type 2 response
(The Rockefeller University Press, 2003) -
Detection of vitamin B12 deficiency in older people by measuring vitamin B12 or the active fraction of vitamin B12, holotranscobalamin.
(American Association for Clinical Chemistry, 2007)Background: Impaired vitamin B12 function and decreased vitamin B12 status have been associated with neurological and cognitive impairment. Current assays analyze total vitamin B12 concentration, only a small percentage ... -
Evidence to support IL-13 as a risk locus for psoriatic arthritis but not psoriasis vulgaris.
(2011)OBJECTIVE: /st> There is great interest in the identification of genetic factors that differentiate psoriatic arthritis (PsA) from psoriasis vulgaris (PsV), as such discoveries could lead to the identification of distinct ... -
Folic acid fortification and public health: report on threshold doses above which unmetabolised folic acid appear in serum
(2007)Background All flour in the USA is fortified with folic acid at a level of 140 ?g/100 g which is estimated to supply an extra 100 ?g daily to the average diet. Some researchers have advocated that this be increased to ... -
Genetic and nutritional factors contributing to hyperhomocysteinemia in young adults
(The American Society of Hematology, 2003)A modestly elevated total plasma homocysteine concentration (tHcy) is generally accepted as an independent and graded risk factor for various pathologies, including vascular diseases, neural tube defects, Alzheimer disease, ... -
Genetic Polymorphisms and the Risk of Infection Following Esophagectomy
(Lippincott Williams & Wilkins, 2007)OBJECTIVE: To examine the association of single nucleotide polymorphisms (SNPs) in inflammation-related genes in the development of infections following esophagectomy. SUMMARY BACKGROUND DATA: Genetic polymorphisms for ... -
A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21
(2007)We tested 310,605 single-nucleotide polymorphisms for association in 778 celiac disease cases and 1422 controls. Outside the HLA, the most significant finding (rs13119723, P=2.0 ? 10?7, empirical genome-wide significance ... -
Helminth infection protects mice from anaphylaxis via IL-10 producing B cells
(The American Association of Immunologists, 2004)Modulation of the immune system by infection with helminth parasites, including schistosomes, is proposed to reduce the levels of allergic responses in infected individuals. In this study we investigated whether experimental ... -
Helminth-modified pulmonary response protects mice from allergen-induced airway hyper-responsiveness.
(The American Association of Immunologists, 2006)It has been shown that the presence of certain helminth infections in humans, including schistosomes, may reduce the propensity to develop allergies in infected populations. Using a mouse model of schistosome worm vs worm ... -
Homocysteine concentration, related B vitamins, and betaine in pregnant women recruited to the Seychelles Child Development Study.
(2008)BACKGROUND: Both folate and betaine are important predictors of total homocysteine (tHcy) during pregnancy. However, studies to date have only been undertaken in populations with Western dietary patterns. OBJECTIVE: We ... -
Human peripheral and gastric lymphocyte responses to Helicobacter pylori NapA and AphC differ in infected and uninfected individuals
(2005)BACKGROUND: In this study, we identify the nature of the immunological response of human peripheral blood mononuclear cells (PBMC) and lamina propria gastric lymphocytes (LPL) to two Helicobacter pylori antigens, the ... -
Identification of a functioning mitochondrial uncoupling protein 1 in thymus
(2005)We present evidence that rat and mouse thymi contain mitochondrial uncoupling protein (UCP 1). Reverse transcriptase-PCR detected RNA transcripts for UCP 1 in whole thymus and in thymocytes. Furthermore, using antibodies ... -
Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion.
(Rockefeller University Press, 2006) -
Impact of the MTHFR C677T polymorphism on risk of neural tube defects:case-control study
(BMJ, 2004)Homozygosity for the T allele of the C677T polymorphism of the gene encoding the folate dependent enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR) is a risk factor for neural tube defects.1 Both the homozygous (TT) ...