The Neuroimaging Features of Frontotemporal Dementia: Characterising Phenotype-Associated Pathological Changes In Vivo
Citation:
McKenna, Mary Clare Síle, The Neuroimaging Features of Frontotemporal Dementia: Characterising Phenotype-Associated Pathological Changes In Vivo, Trinity College Dublin, School of Medicine, Clinical Medicine, 2023Download Item:
Abstract:
Frontotemporal dementia (FTD) is a rare type of dementia. It can
affect language, behaviour and memory depending on what part of the brain
is involved. It can be difficult to diagnose, especially in the early stages of the
disease. The correct diagnosis is important for individual patients and from a
wider research perspective. This research study used advanced magnetic
resonance imaging (MRI) scans to better understand the FTD brain imaging
pattern. These images are mathematically analysed by computers to calculate
the size, shape, density and water diffusivity of different areas within the
brain. Our study focused on (1) evaluating of the thalamus and cerebellum -
which are often under investigated in FTD, and (2) using novel methods to
analyse individual patient brain scans in FTD subtypes. We found that
advanced MRI imaging captures thalamus and cerebellar involvement in FTD,
in a pattern that is unique to each FTD subtype. We also found that novel
methods can be used to reliably interpret individual patients’ brain scans.
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https://tcdlocalportal.tcd.ie/pls/EnterApex/f?p=800:71:0::::P71_USERNAME:MCKENNM6Description:
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Author: McKenna, Mary Clare Síle
Advisor:
Bede, PeterPublisher:
Trinity College Dublin. School of Medicine. Discipline of Clinical MedicineType of material:
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