Browsing Biochemistry (Scholarly Publications) by Title
Now showing items 270-289 of 726
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How tumour necrosis factor blockers interfere with tuberculosis immunity.
(John Wiley, 2010)Tumour necrosis factor (TNF) is a potent inflammatory cytokine that plays an important role in immunity to numerous bacterial infections, including Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB) ... -
The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling
(2006)Toll-like receptors discriminate between different pathogen-associated molecules and activate signaling cascades that lead to immune responses. The specificity of Toll-like receptor signaling occurs by means of adaptor ... -
The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signalling
(2006)Toll-like receptors discriminate between different pathogen-associated molecules and activate signaling cascades that lead to immune responses. The specificity of Toll-like receptor signaling occurs by means of adaptor ... -
HUMAN INTERLEUKIN-1 RECEPTOR ASSOCIATED KINASE-2 (IRAK-2) IS ESSENTIAL FOR TOLL-LIKE RECEPTOR-MEDIATED TRANSCRIPTIONAL AND POSTTRANSCRIPTIONAL REGULATION OF TNFα
(2011)Toll-like receptors (TLRs) are pattern recognition receptors that recognise microbial ligands and subsequently trigger intracellular signalling pathways involving transcription factors such as NF?B and MAPKs such ... -
Human tribbles, a protein family controlling mitogen-activated protein kinase cascades
(American Society for Biochemistry and Molecular Biology, 2004)Control of mitogen-activated protein kinase (MAPK) cascades is central to regulation of many cellular responses. We describe here human tribbles homologues (Htrbs) that control MAPK activity. MAPK kinases interact with ... -
The human tRNA-guanine transglycosylase displays promiscuous nucleobase preference but strict tRNA specificity.
(2021)Base-modification can occur throughout a transfer RNA molecule; however, elaboration is particularly prevalent at position 34 of the anticodon loop (the wobble position), where it functions to influence protein translation. ... -
Humoral response to alpha gliadin as serological screening test for coeliac disease.
(1987)The diagnostic value of measuring alpha gliadin antibodies in children with suspected coeliac disease has been evaluated prospectively. Jejunal biopsy and alpha gliadin antibody measurements were performed in 77 consecutive ... -
Humoral response to wheat protein in patients with coeliac disease and enteropathy associated T cell lymphoma.
(1986)Features that might distinguish uncomplicated coeliac disease from enteropathy associated T cell lymphoma were investigated. Of 76 patients with coeliac disease, 71 (93%) had raised levels of alpha gliadin antibody and all ... -
Identification and Characterization of a Stage Specific Membrane Protein Involved in Flagellar Attachment in Trypanosoma brucei
(2013)Flagellar attachment is a visibly striking morphological feature of African trypanosomes but little is known about the requirements for attachment at a molecular level. This study characterizes a previously undescribed ... -
Identification and Characterization of an Unusual Class I Myosin Involved in Vesicle Traffic in Trypanosoma brucei
(2010)Myosins are a multimember family of motor proteins with diverse functions in eukaryotic cells. African trypanosomes possess only two candidate myosins and thus represent a useful system for functional analysis of these ... -
Identification of filamin C as a new physiological substrate of PKBalpha using KESTREL.
(2004)We detected a protein in rabbit skeletal muscle extracts that was phosphorylated rapidly by PKB ? (protein kinase B ? ), but not by SGK1 (serum- and glucocorticoid-induced kinase 1), and ident- ified it as the ... -
Identification of Plasmepsin Inhibitors as Selective Antimalarial Agents using Ligand Based Drug Design
(Elsevier, 2011)We describe the application of Ligand Based Virtual Screening technologies towards the discovery of novel Plasmepsin (PM) inhibitors, a family of malarial parasitic aspartyl proteases. Pharmacophore queries were used to ... -
IFI16 is an innate immune sensor for intracellular DNA
(2010)The detection of intracellular microbial DNA is critical to appropriate innate immune responses; however, knowledge of how such DNA is sensed is limited. Here we identify IFI16, a PYHIN protein, as an intracellular DNA ... -
IFNL cytokines do not modulate human or murine NK cell functions
(2014)The interferon-lambda (IFNL) cytokines have been shown to be important in HCV infection with SNPs in the IFNL3 gene associated with both natural and treatment induced viral clearance. We have recently shown that rs1299860 ... -
IkappaB kinase epsilon interacts with p52 and promotes transactivation via p65
(The American Society for Biochemistry and Molecular Biology, 2006)The members of the NF-?B transcription factor family are key regulators of gene expression in the immune response. Different combinations of NF-?B subunits not only diverge in timing to induce transcription but also recognize ... -
IL-10 inhibits miR-155 induction by Toll-like receptors.
(2010)IL-10 is a potent anti-inflammatory cytokine that is crucial for down-regulating pro-inflammatory genes which are induced by Toll-like Receptor (TLR) signalling. In this study we have examined whether modulation of micro-RNAs ... -
IL-10 Plays Opposing Roles during Staphylococcus aureus Systemic and Localized Infections.
(2017)IL-10 is a potent anti-inflammatory mediator that plays a crucial role in limiting host immunopathology during bacterial infections by controlling effector T cell activation. Staphylococcus aureus has previously been shown ... -
IL-17 and IL-17-producing cells in protection versus pathology
(2023)IL-17 cytokine family members have diverse biological functions, promoting protective immunity against many pathogens but also driving inflammatory pathology during infection and autoimmunity. IL-17A and IL-17F are produced ... -
IL-17 mediates protective immunity against nasal infection with Bordetella pertussis by mobilizing neutrophils, especially Siglec-F + neutrophils
(2021)Understanding the mechanism of protective immunity in the nasal mucosae is central to the design of more effective vaccines that prevent nasal infection and transmission of Bordetella pertussis. We found significant ...