Browsing Biochemistry (Scholarly Publications) by Title
Now showing items 684-703 of 726
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Toll-like receptor and antimicrobial peptide expression in the bovine endometrium.
(2008)BACKGROUND: The endometrium is commonly infected with bacteria leading to severe disease of the uterus in cattle and humans. The endometrial epithelium is the first line of defence for this mucosal surface against ... -
Topoisomerase II is required for mitoxantrone to signal nuclear factor kappa B activation in HL60 cells
(The American Society for Biochemistry and Molecular Biology, 2000)Topoisomerase II is a target for a number of chemotherapeutic agents used in the treatment of cancer. Its essential physiological role in modifying the topology of DNA involves the generation of transient double-strand ... -
TRAF3: Uncovering the Real but Restricted Role in Human
(2010)In this issue of Immunity, Perez de Diego et al. (2010) report a primary human immune deficiency involving a TRAF protein, and show that human immunity to the virus HSV-1 is critically dependent on TRAF3. -
TRAM is required for TLR2 endosomal signaling to type I IFN induction
(2014)Detection of microbes by TLRs on the plasma membrane leads to the induction of proinflammatory cytokines such as TNF-α, via activation of NF-κB. Alternatively, activation of endosomal TLRs leads to the induction of type I ... -
TRAM is required for TLR2 endosomal signaling to type I IFN induction.
(2014)Detection of microbes by TLRs on the plasma membrane leads to the induction of pro-inflammatory cytokines such as TNF-α, via activation of NF-κB. Alternatively, activation of endosomal TLRs leads to the induction of type ... -
Transactivation by the p65 subunit of NF-kappaB in response to interleukin-1 (IL-1) involves MyD88, IL-1 receptor-associated kinase 1, TRAF-6, and Rac1
(American Society for Microbiology (ASM), 2001)We have examined the involvement of components of the interleukin-1 (IL-1) signaling pathway in the transactivation of gene expression by the p65 subunit of NF-kappaB. Transient transfection of cells with plasmids encoding ... -
Transcriptional Inhibition of the Human Papilloma Virus Reactivates Tumor Suppressor p53 in Cervical Carcinoma Cells
(2007)Inactivation of tumor suppressor p53 accompanies the majority of human malignancies. Restoration of p53 function causes death of tumor cells and is potentially suitable for gene therapy of cancer. In cervical carcinoma, ... -
Transcriptional regulation of the human TRIF (TIR domain-containing adaptor protein inducing interferon beta) gene.
(The Biochemical Society, 2004)TRIF [TIR (Toll/interleukin-1 receptor) domain-containing adaptor protein inducing interferon beta; also known as TICAM-1 (TIR-containing adaptor molecule-1)] is a key adaptor for TLR3 (Toll-like receptor 3)- and TLR4-mediated ... -
Transcriptional up-regulation of ULK1 by ATF4 contributes to cancer cell survival
(2013)Hypoxia in the microenvironment of many solid tumours is an important determinant of malignant progression. The ISR (integrated stress response) protects cells from the ER (endoplasmic reticulum) stress caused by severe ... -
Transmembrane Peptides Stabilize Inverted Cubic Phases in a Biphasic Length-dependent Manner: Implications for Protein-induced Membrane Fusion.
(2006)WALP peptides consist of repeating alanine-leucine sequences of different lengths, flanked with tryptophan ``anchors?? at each end. They form membrane-spanning a-helices in lipid membranes, and mimic protein transmembrane ... -
Tregs and transplantation tolerance
(2004)The induction and maintenance of immune tolerance to transplanted tissues constitute an active process involving multiple mechanisms that work cooperatively to prevent graft rejection. These mechanisms are similar to ... -
Trif-related adapter molecule is phosphorylated by protein kinase C epsilon during Toll-like receptor 4 signalling
(National Academy of Sciences, 2006)PKC? has been shown to play a key role in the effect of the Gram-negative bacterial product LPS; however, the target for PKC? in LPS signaling is unknown. LPS signaling is mediated by Toll-like receptor 4, which uses four ... -
TRIL is involved in cytokine production in the brain following escherichia coli infection
(2014)TLR4 interactor with leucine-rich repeats (TRIL) is a brain-enriched accessory protein that is important in TLR3 and TLR4 signaling. In this study, we generated Tril(-/-) mice and examined TLR responses in vitro and in ... -
The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling
(2007)Signaling by two of the most important bacteria-sensing TLRs, TLR2 and TLR4, involves two adaptor proteins, MyD88 adaptor-like (Mal) and Toll/IL-1 receptor (TIR) domain-containing adaptor-inducing IFN-? (Trif)-related ... -
TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei.
(2015)The metabolic network of a cell represents the catabolic and anabolic reactions that interconvert small molecules (metabolites) through the activity of enzymes, transporters and non-catalyzed chemical reactions. Our ... -
Tumor necrosis factor blockers influence macrophage responses to Mycobacterium tuberculosis
(University of Chicago, 2008)umor necrosis factor (TNF)?? is a proinflammatory cytokine that mediates inflammation in response to various pathogens, including Mycobacterium tuberculosis, but is also a key factor in the pathogenesis of rheumatoid ... -
Turning 21: Induction of miR-21 as a key switch in the inflammatory response
(2015)miR-21 is one of the most highly expressed members of the small non-coding microRNA family in many mammalian cell types. Its expression is further enhanced in many diseased states including solid tumors, cardiac injury, ... -
Two new and rapid approaches for studying the phase properties of cosmetic lipids and oils
(Society of Cosmetic Chemists, 1988)Lipids and oils, integral components of cosmetic products, exist in a number of intermediate physical states, or mesomorphic phases, between the crystalline solid and isotropic liquid. The stability of these phases depends ... -
Type ii nkt cell agonist, sulfatide, is an effective adjuvant for oral heat-killed cholera vaccines
(2021)Oral vaccination has the potential to offer a safer and more efficacious approach for protection against enteric pathogens than injection-based approaches, especially in developing countries. One key advantage is the ...