Browsing Biochemistry (Scholarly Publications) by Title
Now showing items 699-718 of 726
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TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei.
(2015)The metabolic network of a cell represents the catabolic and anabolic reactions that interconvert small molecules (metabolites) through the activity of enzymes, transporters and non-catalyzed chemical reactions. Our ... -
Tumor necrosis factor blockers influence macrophage responses to Mycobacterium tuberculosis
(University of Chicago, 2008)umor necrosis factor (TNF)?? is a proinflammatory cytokine that mediates inflammation in response to various pathogens, including Mycobacterium tuberculosis, but is also a key factor in the pathogenesis of rheumatoid ... -
Turning 21: Induction of miR-21 as a key switch in the inflammatory response
(2015)miR-21 is one of the most highly expressed members of the small non-coding microRNA family in many mammalian cell types. Its expression is further enhanced in many diseased states including solid tumors, cardiac injury, ... -
Two new and rapid approaches for studying the phase properties of cosmetic lipids and oils
(Society of Cosmetic Chemists, 1988)Lipids and oils, integral components of cosmetic products, exist in a number of intermediate physical states, or mesomorphic phases, between the crystalline solid and isotropic liquid. The stability of these phases depends ... -
Type ii nkt cell agonist, sulfatide, is an effective adjuvant for oral heat-killed cholera vaccines
(2021)Oral vaccination has the potential to offer a safer and more efficacious approach for protection against enteric pathogens than injection-based approaches, especially in developing countries. One key advantage is the ... -
Tyrosine phosphorylation of MyD88 adapter-like (Mal) is critical for signal transduction and blocked in endotoxin tolerance
(American Society for Biochemistry and Molecular Biology, 2008)Toll-like receptor 4 (TLR4) recognition of lipopolysaccharide triggers signalosome assembly among TLR4, sorting (e.g. MyD88 adapter-like (Mal)) and signaling (e.g. MyD88) adapters, initiating recruitment and activation of ... -
UCP3 reciprocally controls CD4+ Th17 and Treg cell differentiation
(2020)Uncoupling proteins (UCPs) are members of the mitochondrial anion carrier superfamily that can mediate the transfer of protons into the mitochondrial matrix from the intermembrane space. We have previously reported UCP3 ... -
Uncoupling mechanism and redox regulations of mitochondrial uncoupling protein UCP1
(2018)Brown adipose tissue (BAT) and brown in white (brite) adipose tissue, termed also beige adipose tissue, are major sites of mammalian nonshivering thermogenesis. Mitochondrial uncoupling protein 1 (UCP1), specific for these ... -
Unexpected roles for DEAD-box protein 3 in viral RNA sensing pathways
(2010)Detection of viral nucleic acid within infected cells is essential to an effective antiviral response. The retinoic acid-inducible gene-I (RIG-I)-like receptors (RLR) form part of the virus detection repertoire and are ... -
Unravelling the immunomodulatory effects of viral ion channels, towards the treatment of disease
(2021)The current COVID-19 pandemic has highlighted the need for the research community to develop a better understanding of viruses, in particular their modes of infection and replicative lifecycles, to aid in the development ... -
Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome.
(2009)Many currently used and candidate vaccine adjuvants are particulate in nature, but their mechanism of action is not well understood. Here, we show that particulate adjuvants, including biodegradable poly(lactide-co-glycolide) ... -
Use of a Robot for High-throughput Crystallization of Membrane Proteins in Lipidic Mesophases
(2012)An important route to understanding how proteins function at a mechanistic level is to have the structure of the target protein available, ideally at atomic resolution. Presently, there is only one way to capture such ... -
Vaccine trials during a pandemic: potential approaches to ethical dilemmas
(2021)Ever since the emergence of the coronavirus disease 2019 (COVID-19), global public health infrastructures and systems, along with community-wide collaboration and service, have risen to an unprecedented challenge. ... -
Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence
(2005)Viral immune evasion strategies target key aspects of the host antiviral response. Recently, it has been recognized that Toll-like receptors (TLRs) have a role in innate defense against viruses. Here, we define the function ... -
Vaccinia Virus Protein C6 Is a Virulence Factor that Binds TBK-1 Adaptor Proteins and Inhibits Activation of IRF3 and IRF7
(2011)Recognition of viruses by pattern recognition receptors (PRRs) causes interferon-? (IFN-?) induction, a key event in the anti-viral innate immune response, and also a target of viral immune evasion. Here the vaccinia virus ... -
Variant in CD209 promoter is associated with severity of liver disease in chronic hepatitis C virus infection
(2010)CD209, a c-type lectin expressed by dendritic cells (DCs), acts as a pathogen recognition receptor. A single nucleotidepolymorphism (SNP) in the promoter region of CD209(-336A/G;rs4804803) affects transcription and is ... -
A variant in the CD209 promoter is associated with the severity of liver disease in chronic Hepatitis C virus infection
(2010)CD209, a c-type lectin expressed by dendritic cells (DCs) acts as a pathogen recognition receptor. A single nucleotide polymorphism (SNP) in the promoter region of CD209 (-336 A/G; rs4804803) affects transcription and is ... -
Variation in Both IL28B and KIR2DS3 Genes Influence Pegylated Interferon and Ribavirin Hepatitis C Treatment Outcome in HIV-1 Co-Infection
(2013)Pegylated-IFN and ribavirin remains the current treatment for chronic HCV infection in patients co-infected with HIV-1, but this regimen has low efficacy rates, particularly for HCV genotype 1/4 infection, has severe side ... -
Viral Inhibitory Peptide of TLR4, a Peptide Derived from Vaccinia Protein A46, Specifically Inhibits TLR4 by Directly Targeting MyD88 Adaptor-Like and TRIF-Related Adaptor Molecule
(2010)TLRs are critical pattern recognition receptors, which recognize bacterial and viral pathogen associated molecular patterns leading to innate and adaptive immune responses. TLRs signal via homotypic interactions between ... -
Vitamin C inhibits NF-kappa B activation by TNF via the activation of p38 mitogen-activated protein kinase
(2000)The transcription factor NF-kappaB is a central mediator of altered gene expression during inflammation, and is implicated in a number of pathologies, including cancer, atherosclerosis, and viral infection. We report in ...