Browsing Biochemistry (Scholarly Publications) by Author "DUNNE, AISLING"
Now showing items 1-10 of 10
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Activation of biliverdin-IXα reductase by inorganic phosphate and related anions
MANTLE, TIMOTHY; FRANKLIN, EDWARD; DUNNE, AISLING; HAYES, JERRARD (2007)The effect of pH on the initial-rate kinetic behaviour of BVR-A (biliverdin-IX? reductase) exhibits an alkaline optimum with NADPH as cofactor, but a neutral optimum with NADH as cofactor. This has been described as dual ... -
DNA sensors are expressed in astrocytes and microglia in vitro and are upregulated during gliosis in neurodegenerative disease
CUNNINGHAM, COLM; BOWIE, ANDREW; DUNNE, AISLING; COX, DONAL (2015)The detection of nucleic acids by the innate immune system is an essential host response during viral infection. In recent years, a number of immune sensors capable of recognizing cytosolic DNA have been identified and ... -
A functional variant in MAL/TIRAP and protection against invasive pneumococcal disease, bacteraemia, malaria and tuberculosis
O'NEILL, LUKE ANTHONY JOHN; DUNNE, AISLING (2007)Toll-like receptors (TLRs) and members of their signaling pathway are important in the initiation of the innate immune response to a wide variety of pathogens1, 2, 3. The adaptor protein Mal (also known as TIRAP), encoded ... -
Inflammasome activation by adenylate cyclase toxin directs Th17 responses and protection against Bordetella pertussis.
MILLS, KINGSTON; SUTTON, CAROLINE; ROSS, PADRAIG; DUNNE, AISLING (2010)Inflammasome-mediated IL-1? production is central to the innate immune defects that give rise to certain autoinflammatory diseases and may also be associated with the generation of IL-17?producing CD4+ T (Th17) cells that ... -
MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction
O'NEILL, LUKE ANTHONY JOHN; DUNNE, AISLING (2006)Members of the Toll-like receptor (TLR) family are essential players in activating the host innate immune response against infectious microorganisms. All TLRs signal through Toll/interleukin 1 receptor domain-containing ... -
NF-kappaB activation by the Toll-IL-1 receptor domain-containing protein Mal is regulated by caspase-1
O'NEILL, LUKE ANTHONY JOHN; PALSSON MCDERMOTT, EVA; BANAHAN, KATHY; DUNNE, AISLING (2007)Toll-like receptors (TLRs)-2 and -4 are important proteins in innate immunity, recognizing microbial products and eliciting host defense responses. Both use the adapter proteins MyD88 and MyD88 adapter-like (Mal) to activate ... -
Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88
O'NEILL, LUKE ANTHONY JOHN; DUNNE, AISLING (2003)The Toll/interleukin 1 receptor (TIR) domain is a region found in the cytoplasmic tails of members of the Toll-like receptor/interleukin-1 receptor superfamily. The domain is essential for signaling and is also found in ... -
Toll-like receptor (TLR) 3 signaling requires the TLR4 interactor with leucine-rich repeats (TRIL).
CARPENTER, SUSAN; DUNNE, AISLING; O'NEILL, LUKE (2011)Toll-like (TLRs) receptors are a family of proteins that act as the primary sensors of microbial products. Many TLRs require accessory molecules in order to recognize these microbial products and initiate signal transduction ... -
TRIL is involved in cytokine production in the brain following escherichia coli infection
DUNNE, AISLING; O'NEILL, LUKE (2014)TLR4 interactor with leucine-rich repeats (TRIL) is a brain-enriched accessory protein that is important in TLR3 and TLR4 signaling. In this study, we generated Tril(-/-) mice and examined TLR responses in vitro and in ...