Browsing Biochemistry (Scholarly Publications) by Author "MCCOY, CLAIRE"
Now showing items 1-3 of 3
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IL-10 inhibits miR-155 induction by Toll-like receptors.
O'NEILL, LUKE; DOYLE, SARAH; MCCOY, CLAIRE; SHEEDY, FREDERICK JOHN; QUINN, SUSAN; SHEEDY, FREDERICK (2010)IL-10 is a potent anti-inflammatory cytokine that is crucial for down-regulating pro-inflammatory genes which are induced by Toll-like Receptor (TLR) signalling. In this study we have examined whether modulation of micro-RNAs ... -
A Role for TLR4 in Clostridium difficile Infection and the Recognition of Surface Layer Proteins
O'NEILL, LUKE; AMU, SYLVIE; MCCOY, CLAIRE; MORTON, CHARLES; ROGERS, THOMAS; FALLON, PADRAIC; KELLEHER, DERMOT (2011)Clostridium difficile is the etiological agent of antibiotic-associated diarrhoea (AAD) and pseudomembranous colitis in humans. The role of the surface layer proteins (SLPs) in this disease has not yet been fully explored. ... -
The role of Ets2 transcription factor in the induction of microRNA-155 by LPS, and its targeting by IL-10.
O'NEILL, LUKE; MCCOY, CLAIRE; QUINN, SUSAN (2014)MicroRNA-155 (miR-155) is highly expressed in many cancers such as B cell lymphomas and myeloid leukaemia, and inflammatory disorders such as rheumatoid arthritis, atopic dermatitis and multiple sclerosis. The role ...