Browsing Biochemistry (Scholarly Publications) by Author "Mc Loughlin, Rachel"
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Clumping factor B is an important virulence factor during Staphylococcus aureus skin infection and a promising vaccine target
Mc Loughlin, Rachel; Lacey, Keenan A.; Mulcahy, Michelle E.; Towell, Aisling M.; Geoghegan, Joan A. (2019)Staphylococcus aureus expresses a number of cell wall-anchored proteins that mediate adhesion and invasion of host cells and tissues and promote immune evasion, consequently contributing to the virulence of this organism. ... -
IL-10 Plays Opposing Roles during Staphylococcus aureus Systemic and Localized Infections.
Mc Loughlin, Rachel; Leech, John M.; Lacey, Keenan A.; Mulcahy, Michelle E.; Medina, Eva (2017)IL-10 is a potent anti-inflammatory mediator that plays a crucial role in limiting host immunopathology during bacterial infections by controlling effector T cell activation. Staphylococcus aureus has previously been shown ... -
Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection.
Geoghegan, Joan; Rogers, Thomas; Mac Aogáin, Micheál; Mc Loughlin, Rachel; Lavelle, Edward; Foster, Timothy; Fennell, Jerome; Lalor, Stephen (2015)Mechanisms of protective immunity to Staphylococcus aureus infection in humans remain elusive. While the importance of cellular immunity has been shown in mice, T cell responses in humans have not been characterised. Using ... -
Next-generation anti-Staphylococcus aureus vaccines: A potential new therapeutic option for atopic dermatitis?
Irvine, Alan; Mc Loughlin, Rachel; Clowry, Julianne (2019)Disease severity in patients with atopic dermatitis (AD) isdirectly correlated with colonization by Staphylococcus aureus.1 An increasing body of evidence now also supports a role for Saureusin the pathogenesis of AD in ... -
Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4.
Lavelle, Edward; Moran, Barry; Mc Loughlin, Rachel (2010)Pneumolysin (PLY) is a key Streptococcus pneumoniae virulence factor and potential candidate for inclusion in pneumococcal subunit vaccines. Dendritic cells (DC) play a key role in the initiation and instruction of adaptive ... -
Targeted nasal vaccination provides antibody-independent protection against staphylococcus aureus
Lavelle, Edward; Mc Loughlin, Rachel (2014)Despite showing promise in preclinical models, anti – Staphylococcus aureus vaccines have failed in clinical trials. To date, approaches have focused on neutralizing/opsoniz- ing antibodies; however, vaccines exclusively ... -
TRAM is required for TLR2 endosomal signaling to type I IFN induction
Bowie, Andrew; Mc Loughlin, Rachel (2014)Detection of microbes by TLRs on the plasma membrane leads to the induction of proinflammatory cytokines such as TNF-α, via activation of NF-κB. Alternatively, activation of endosomal TLRs leads to the induction of type I ... -
Would hemodialysis patients benefit from a Staphylococcus aureus vaccine?
Mc Loughlin, Rachel; Connolly, Roisin; Denton, Mark D.; Humphreys, Hilary (2019)Staphylococcus aureus bloodstream infection can have potentially catastrophic consequences for patients on hemodialysis. Consequently, an effective vaccine to prevent S aureus infection would have a significant influence ...