Browsing School of Chemistry by Author "O'Sullivan, Patrick"
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Guanidine-based DNA binders and strategies toward their platinum complexes as anticancer dual agents
O'Sullivan, Patrick (Trinity College (Dublin, Ireland). School of Chemistry, 2016)One in three people will be diagnosed with cancer in their lifetime. One of the main targets of chemotherapy is DNA. Platinum-based anti-cancer agents form covalent bonds with bases in the major groove of DNA in cancer ...