Browsing Clinical Medicine (Scholarly Publications) by Subject "Oncology"

Now showing items 1-8 of 8

    • Endothelin inhibitors for advanced prostate cancer 

      HOLLYWOOD, DONAL; FOLEY, RUTH (John Wiley, 2011)
      This is the protocol for a review and there is no abstract. The objectives are as follows: Our review aims to determine the effectiveness and adverse effects of endothelin inhibitors for advanced prostate cancer. The ...

    • Epigenetic Regulation of Glucose Transporters in Non-Small Cell Lung Cancer 

      O'BYRNE, KEN; BAIRD, ANNE-MARIE; GRAY, STEVEN (MDPI, 2011)
      Due to their inherently hypoxic environment, cancer cells often resort to glycolysis, or the anaerobic breakdown of glucose to form ATP to provide for their energy needs, known as the Warburg effect. At the same time, ...

    • Epigenetics Underpinning the Regulation of the CXC (ELR+) Chemokines in Non-Small Cell Lung Cancer 

      O'BYRNE, KEN; BAIRD, ANNE-MARIE; GRAY, STEVEN (PLoS, 2011)
      Background: Angiogenesis may play a role in the pathogenesis of Non-Small Cell Lung cancer (NSCLC). The CXC (ELR+) chemokine family are powerful promoters of the angiogenic response. Methods: The expression of the CXC ...

    • NF-κB regulation: The nuclear response 

      Mc Manus, Ross; Gray, Steven; Kelleher, Dermot (2009)
      Nuclear factor ?B (NF-?B) is an inducible transcription factor that tightly regulates the expression of a large cohort of genes. As a key component of the cellular machinery NF-?B is involved in a wide range of biological ...

    • Platelet Adhesion and Degranulation Induce Pro-Survival and Pro-Angiogenic Signalling in Ovarian Cancer Cells 

      SMYTH, PAUL; O'LEARY, JOHN; O'TOOLE, SHARON; SPILLANE, CATHY; MARTIN, CARA; GALLAGHER, MICHAEL; NORRIS, LUCY; CONLON, NIAMH; MCEVOY, LYNDA MARIE; FFRENCH, GEORGE BRENDAN; STORDAL, BRITTA; KEEGAN, HELEN; FINN, STEPHEN; MCENEANEY, VICTORIA; SHEILS, ORLA; CROWLEY, DARRAGH (2011)
      Thrombosis is common in ovarian cancer. However, the interaction of platelets with ovarian cancer cells has not been critically examined. To address this, we investigated platelet interactions in a range of ovarian cancer ...

    • Receptor tyrosine kinases and their activation in melanoma. 

      GRAY, STEVEN; O'DONNELL, DEARBHAILE; O'BYRNE, KEN (2011)
      Receptor tyrosine kinases (RTKs) and their downstream signalling pathways have long been hypothesized to play key roles in melanoma development. A decade ago, evidence was derived largely from animal models, RTK expression ...

    • The Role of Epigenetics in Resistance to Cisplatin Chemotherapy in Lung Cancer 

      O'BYRNE, KEN; BARR, MARTIN; GRAY, STEVEN (2011)
      Non-small cell lung cancer (NSCLC) is the most common cause of cancer related death in the world. Cisplatin and carboplatin are the most commonly used cytotoxic chemotherapeutic agents to treat the disease. These agents, ...

    • The role of epigenetics in resistance to cisplatin chemotherapy in lung cancer 

      GRAY, STEVEN; BARR, MARTIN; O'BYRNE, KEN (2011)
      Non-small cell lung cancer (NSCLC) is the most common cause of cancer related death in the world. Cisplatin and carboplatin are the most commonly used cytotoxic chemotherapeutic agents to treat the disease. These agents, ...