Browsing Mechanical & Manufacturing Eng (Theses and Dissertations) by Title
Now showing items 180-199 of 219
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Spatial presentation of tissue specific extracellular matrix components and growth factors on porous electrospun fibre scaffolds for bone-ligament interface tissue engineering
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2018)In many clinical situations ligament or tendon replacements are required, such as for the surgical replacement of a torn anterior cruciate ligament (ACL). The current ‘gold standard’ treatment is resection of the torn ... -
Stochastic failure modelling of total hip replacement
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2009)Failure of total hip replacement (THR) can be a highly variable phenomenon. Many factors of a different nature may affect the outcome of this operation, e.g. loads occuring in the joint, patient geometry, implant design, ... -
Stress concentrations in bone cement : a critical distance approach
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2009)Bone cement is a biomaterial which is used in the fixation of orthopaedic implants. Despite its extensive use it is regarded as the 'weak link' in cemented arthroplasties, fatigue failure of the cement mantle being a major ... -
Targeted bone remodelling : investigating the scissors model
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2013)Bone is continually being removed and replaced through the actions of basic multicellular units (BMU). This constant upkeep is necessary to remove microdamage and thus maintain the integrity of the bone. Microdamage forms ... -
Temporomandibular joint injuries during whiplash
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2000)Whiplash injuries occur due to differential accelerations in the human body. Neck injuries are predominant, but a considerable body of clinical evidence suggesting a close relationship between whiplash and temporomandibular ... -
Tension and compression stress-strain asymmetry in passive skeletal muscle
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2017)The general aim of this study is to advance the knowledge of the relationship between the skeletal muscle passive compressive and tensile behaviour, and the microstructure of the muscle through combined experimental, ... -
The cellular transducer in damage-stimulated bone remodelling
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2004)People with osteoporosis, osteopenia or weight baring joint replacement, due to an altered loading configuration, are more susceptible to microdamage accumulation than normal human beings as are athletes who undertake ... -
The characterisation of electrical energy consumption in complex manufacturing process chains
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2013)The combination of increasing energy costs, corporate image concerns, and environmental legislation is driving a transition towards energy and resource efficiency within the manufacturing sector. Developing a more comprehensive ... -
The developement of novel scaffolds for tissue engineering with a range of structural and mechanical properties
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2009)Tissue engineering (or regenerative medicine) is defined as the application of scientific principles to the synthesis of living tissues using bioreactors, cells, scaffolds, growth factors, or a combination (Rose and Oreffo, ... -
The development of a surface acoustic wave strain sensor
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2011)Multi sensors networks are becoming increasingly prevalent in modern engineering applications. In multi sensor networks, wireless sensors are preferred over traditional wired methods. Sensors based upon the surface acoustic ... -
The development of an active implantable neural probe system for chronic use
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2017)The alleviation of symptoms of debilitating neural conditions via neural probes is an increasingly important area of research. However, the effectiveness of these probes decreases over time due to the formation of a glial ... -
The effect of bone turnover on bone quality and material properties
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2008)Coined in French in the 1820s as a description of a pathological state of bone tissue, the term osteoporosis made its way into the English language only in the 20th century. Unlike other medical concepts, which have not ... -
The effect of cyclic tensile loading and growth factors on the chondrogenic differentiation of bone-marrow derived mesenchymal stem cells in a collagen-glycosaminoglycan scaffold
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2007)Adult mesenchymal stem cells (MSCs) offer great potential in tissue engineering applications as they can be directed to differentiate along numerous lineages to produce a range of skeletal tissues, including the chondrogenic ... -
The effect of mechanical cues on the chondrogenic differentiation of bone marrow derived mesenchymal stem cells
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2012)Tissue engineering strategies utilising mesenchymal stem cells (MSCs) represent a promising treatment option for a range of injuries and diseases. If MSCs are to be implanted in vivo, understanding the intricacies of how ... -
The effect of stress concentrations on fatigue and fracture of 316L stainless steel micro-scale components
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2004)The aim of this work was to investigate the fatigue and fracture behaviour of microscopic specimens based on a biomedical component (the cardiovascular stent) and to modify existing theories to take account of the observed ... -
The effects of a sliding air bubble on heat transfer from an inclined surface
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2011)An investigation into the effect of a single sliding air bubble on heat transfer from a submerged, inclined surface has been performed. It is known that bubbles, both vapour and gas, can increase heat transfer rates from ... -
The evolution of an impinging synthetic air jet
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2013)Impinging synthetic jets are considered to offer great potential for many applications, including the thermal management of electronics. In this study, an experimental investigation into the evolution of an impinging ... -
The fatigue behaviour of three-dimensional stress concentrations
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2003)The fatigue behaviour of complex three-dimensional notched components is a subject of great practical interest to industrial engineers. Unfortunately, the analysis of this type of feature presents problems for most assessment ... -
The influence of chevrons on the turbulent characteristics of jets
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2010)To minimize the significant environmental impact of air travel a reduction in noise pollution from jet engines is required. This has led to a renewed focus on active and passive techniques which modify the turbulence ... -
The influence of scoliosis and wheechair customisations in rear impact
(Trinity College (Dublin, Ireland). Department of Mechanical and Manufacturing Engineering, 2009)Considerable advances in wheelchair occupant frontal impact safety have been achieved, but further research in rear impact is required. Future analysis would benefit from more biofidelic representation of wheelchair ...
