Browsing Genetics (Theses and Dissertations) by Title
Now showing items 132-151 of 196
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Olfactory-avoidance habituation in Drosophila melanogaster
(Trinity College (Dublin, Ireland). Department of Genetics, 2015)Habituation is a form of sensory filtering in response to prolonged or repeated stimuli in the environment [Harris, 1943; Thompson and Spencer, 1966; Christoffersen, 1997; Rankin et al., 2009], It provides biological ... -
On the development of animal models for degenerative retinal disease
(Trinity College (Dublin, Ireland). Department of Genetics, 2000)Retinitis pigmentosa (RP) is one of the leading causes of inherited blindness within the working population of many developed countries. There is presently no cure for this disorder. The projects outlined in this thesis ... -
On the development of molecular approaches to therapy for retinitis pigmentosa
(Trinity College (Dublin, Ireland). Department of Genetics, 2013)Endothelial cells lining the microvasculature of the retina have highly evolved “tight junctions” reducing the space between adjacent cells to form a selective and highly regulatable barrier called the inner blood-retina ... -
On the genetics of retinal function and disease
(Trinity College (Dublin, Ireland). Department of Genetics, 2006)There are many recorded examples in which genetic background has been shown to radically influence retinal phenotypes in inbred mouse strains. For example, the manifestations of a targeted knockout of the p53 gene are much ... -
On the molecular genetics of bipolar affective disorder
(Trinity College (Dublin, Ireland). Department of Genetics, 2005)This thesis describes genome-wide gene mapping analyses as applied to bipolar affective disorder (BPAD). This condition is a severe recurrent psychiatric disorder, with a substantial familial component and an estimated ... -
On the molecular genetics of bipolar disorder
(Trinity College (Dublin, Ireland). Department of Genetics, 2003)A modified genome scan, concentrating primarily on gene rich regions of the genome was employed by this group to search for regions harboring susceptibility loci for bipolar disorder in a panel of 48 Irish sib-pair families ... -
On the molecular genetics of hereditary degenerative retinopathies
(Trinity College (Dublin, Ireland). Department of Genetics, 2004)The central aim of this thesis was the elucidation of the underlying molecular pathologies of inherited diseases of the retina. The main focus of study concentrates on the molecular genetics and disease mechanisms in ... -
On the molecular genetics of retinal dystrophies and glaucoma
(Trinity College (Dublin, Ireland). Department of Genetics, 2000)The central aim of this thesis was the elucidation of the underlying molecular pathologies of inherited diseases of the eye. Previous linkage studies on a large Spanish kindred (family FA-84), segregating adRP, resulted ... -
On the role of caspase-recruitment domain proteins in apoptosis and NFkB activation
(Trinity College (Dublin, Ireland). Department of Genetics, 2002)Apoptosis and NFkB activation are two physiological processes that are essential for host mediated response to cellular injury. Apoptosis is a mechanism that removes damaged or unwanted cells. NFkB is a transcription factor ... -
On the Use of Machine Learning in Genomic Prediction
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2023)This thesis explores the use of machine learning in the context of genomic prediction and the issue of confounding in such approaches. Traditionally, genomic prediction methods have made use of linear models with much ... -
Optimisation of a suppression and replacement therapeutic strategy for animal models of rhodopsin-linked autosomal dominant Retinitis Pigmentosa
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2012)The focus of research presented in this PhD thesis was optimising a therapeutic strategy for an inherited retinal disorder termed Retinitis Pigmentosa (RP). RP is a disease in which the photoreceptors progressively degenerate. ... -
Optimisation of therapies for inherited retinal and mitochondrial diseases
Inherited retinal degenerations (IRDs) are the most frequent cause of vision loss in people of working age. They have highly varied causes and pathophysiologies, and are typically incurable. Gene therapy has emerged as a ... -
Over-expression of SNAP-25 in neuronal tissues
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2012)The work described within this PhD thesis represents many years work on several different projects. In brief, SNAP-25 was identified as a downregulated candidate gene of interest from a comparative microarray study in the ... -
Patterns of regulation of gene expression and genetic novelty in mammalian species
(Trinity College (Dublin, Ireland). Department of Genetics, 2012)Genetic novelty is the driving force behind evolution. Consequently, a large amount of genetic research is dedicated to determining the mechanisms behind, and the effects of, the creation of new genes. Where and when these ... -
Persistent, ancient constraints shape copy number and expression variation of dosage-sensitive genes
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2017) -
Picking the high hanging fruit : automated ways to annotate awkward genes
(Trinity College (Dublin, Ireland). Department of Genetics, 2012)In Chapter 2 I describe the development of software called SearchDOGS (Database of Orthologous Genomic Segments). By identifying regions of conserved local synteny across species using the synteny information contained in ... -
Population and genomic variation of immune genes in chicken
(Trinity College (Dublin, Ireland). Department of Genetics, 2010)Achieving an understanding of the processes shaping diversity at chicken immune genes illuminates their population history, relevance to disease and mechanisms of evolution. Functional variation at genes that determine the ... -
Population genetics of modern and ancient cattle
(Trinity College (Dublin, Ireland). School of Genetics and Microbiology, 2011)The domestication of cattle was a milestone in human history. It is widely accepted that cattle were domesticated in at least two independent domestication events; the Fertile Crescent was the primary domestication centre ... -
Post-polyploidy evolution in yeasts
(Trinity College (Dublin, Ireland). Department of Genetics, 2007)Whole-genome duplication (WGD) and gene duplication are topics central to the study of genome evolution. With the availability of genome sequences for both paleopolyploid (post-WGD) and non-polyploid outgroup (pre-WGD) ... -
Primary open-angle glaucoma: on the development of novel therapeutic approaches
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2018)Glaucoma is one of the most prevalent forms of preventable blindness, affecting more than 60 million people worldwide. While normotensive forms of the disease do exist, the majority of cases are caused by elevations in ...
