Browsing Clinical Medicine by Title
Now showing items 660-679 of 949
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P-glycoprotein expression and function, relationship to plasma and intracellular drug concentrations, and the effects of HIV disease
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2007)P-glycoprotein Expression and Function: Peripheral blood lymphocytes (PBMCs) were isolated by Ficoll density gradient centrifugation, fixed and permeabilised. P- glycoprotein (P-gp) expression was quantified by flow cytometry ... -
Palliative care in amyotrophic lateral sclerosis: a review of current international guidelines and initiatives
(BMJ, 2011)Background: Amyotrophic lateral sclerosis (ALS) is a relentlessly progressive neurodegenerative condition. Optimal management requires a palliative approach from diagnosis with emphasis on patient autonomy, dignity and ... -
Palliative care in the era of novel oncological interventions: needs some "tweaking"
(2022)Cancer treatment has evolved enormously over the last 20 years, with developments in surgery, radiotherapy, chemo- therapy, targeted therapy, and immunotherapy. As a result, many cancer patients have improved outcomes ... -
Participation of MyD88 and interleukin-33 as innate drivers of Th2 immunity to Trichinella spiralis.
(2013)Trichinella spiralis is a highly destructive parasitic nematode that invades and destroys intestinal epithelial cells, injures many different tissues during its migratory phase, and occupies and transforms myotubes during ... -
Particulate air pollution and mortality in Dublin 1980-1996
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2000)Air pollution in Dublin was studied for the period from 1980 to 1996. The factors which contribute to air pollution were investigated, and the nature of particulate air pollution is discussed. The trends in air pollution, ... -
The path to specialist multidisciplinary care in amyotrophic lateral sclerosis: A population- based study of consultations, interventions and costs.
(2017)Background: Amyotrophic Lateral Sclerosis (ALS) is a devastating neurological condition that requires coordinated, multidisciplinary clinical management. ALS is prone to misdiagnosis as its signs and symptoms may be ... -
The Pathological Associations of Hyperuricaemia in Sub-Clinical Gout, Cardiovascular and Cardiopulmonary Diseases
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Abstract - Introduction Gout is a common and treatable disease caused by the deposition of MSU crystals in articular and non-articular structures. Hyperuricaemia is the most important risk factor for the development of ... -
Patient journey to a specialist amyotrophic lateral sclerosis multidisciplinary clinic: an exploratory study.
(2015)BACKGROUND: The multidisciplinary approach in the management of Amyotrophic Lateral Sclerosis (ALS) has been shown to provide superior care to devolved care, with better survival, improved quality of care, and quality ... -
Patterns of Transcriptional Response to 1,25-Dihydroxyvitamin D3 and Bacterial Lipopolysaccharide in Primary Human Monocytes.
(2016)The active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25D), plays an important immunomodulatory role, regulating transcription of genes in the innate and adaptive immune system. The present study examines patterns of ... -
Pauci Immune crescentic glomerulonephritis in a patient with T-cell lymphoma and argyria
(2016)Background: Silver is a transition metal, toxic when ingested in significant amounts, causing argyria (skin deposition) and argyrosis (eye deposition). It is excreted mainly via the gastrointestinal tract with only small ... -
Pellino3 ubiquitinates RIP2 and mediates NOD2-induced signaling and protective effects in colitis
(2013)Mutations that result in loss of function of Nod2, an intracellular receptor for bacterial peptidoglycan, are associated with Crohn's disease. Here we found that the E3 ubiquitin ligase Pellino3 was an important mediator ... -
Performance measures for small-bowel endoscopy: a European Society of Gastrointestinal Endoscopy (ESGE) Quality Improvement Initiative.
(2019)The European Society of Gastrointestinal Endoscopy (ESGE) together with the United European Gastroenterology (UEG) recently developed a short list of performance measures for small-bowel endoscopy (i.e. small-bowel capsule ... -
Personalised Medicine in ANCA-Associated Vasculitis: The Role of Urine Soluble CD163
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)In this thesis I have identified a highly sensitive and specific association between urinary sCD163 and active renal vasculitis in the clinical setting of renal vasculitis flare in both retrospective and prospective studies. ... -
A phase III trial of tirasemtiv as a potential treatment for amyotrophic lateral sclerosis
(Informa Healthcare, 2019)Objective: To assess the efficacy of tirasemtiv, a fast skeletal muscle troponin activator, vs. placebo in patients with amyotrophic lateral sclerosis. Methods: VITALITY-ALS (NCT02496767) was a multinational, double-blind, ... -
Phenotype and Function of CD25-Expressing B Lymphocytes Isolated from Human Umbilical Cord Blood
(2011)Background. We have shown that approximately 30% of human peripheral blood B-cells express CD25. B cells expressing CD25 display a mature phenotype belonging to the memory B-cell population and have a better proliferative ...