Browsing Clinical Medicine by Title
Now showing items 680-699 of 949
-
Phosphorylation of Rab5a Protein by Protein Kinase Cϵ Is Crucial for T-cell Migration.
(2014)Rab GTPases control membrane traffic and receptor-mediated endocytosis. Within this context, Rab5a plays an important role in the spatial regulation of intracellular transport and signal transduction processes. Here, we ... -
Phosphorylation of Rab5a protein by protein kinase Cϵ Is crucial for T-cell migration
(2014)Rab GTPases control membrane traffic and receptor-mediated endocytosis. Within this context, Rab5a plays an important role in the spatial regulation of intracellular transport and signal transduction processes. Here, we ... -
Physical Activity and Amyotrophic Lateral Sclerosis: A European Population-Based Case Control Study
(2014)OBJECTIVE: To assess whether physical activity is a risk factor for amyotrophic lateral sclerosis (ALS). METHODS: From February 2008 to April 2012, 652 patients with ALS from European population-based registries ... -
Physical activity level and barriers to physical activity among an adult type 1 diabetes population
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)Context: Information on physical activity (PA) levels and its association with glycaemic control and cardiovascular disease (CVD) risk is lacking among Irish adults with T1DM. Aims: (1) PA levels were assessed in this ... -
Physical function in community-dwelling older adults - a focus on health inequality and ageing in place
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)This thesis sought to explore socioeconomic determinants of physical function in community-dwelling older adults, with implications for ageing in place. While several markers of physical function are explored in this thesis, ... -
Physical functioning and health-outcomes following hospitalisation with COVID-19: a longitudinal cohort study
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2023)Introduction: A novel coronavirus (severe acute respiratory syndrome coronavirus 2; SARS-CoV-2) emerged in Wuhan, China in late 2019, causing an outbreak of viral pneumonia. Initial studies published focused on the management ... -
The Plasticity of Neutrophil Subsets in Inflammation
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Neutrophils are a vital component of the innate immune system and the body s first line of defense against invading pathogens. The classic view of these cells is that they are a homogenous population of terminally ... -
Platelet activation status, on-treatment platelet reactivity and reticulated platelets in the early and late phases after TIA/ischaemic stroke
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Aims: This thesis aimed to assess platelet activation status, on-treatment platelet reactivity and the profile of reticulated platelets in patients with ischaemic cerebrovascular disease (CVD) who were commencing or changing ... -
Platelet Adhesion and Degranulation Induce Pro-Survival and Pro-Angiogenic Signalling in Ovarian Cancer Cells
(2011)Thrombosis is common in ovarian cancer. However, the interaction of platelets with ovarian cancer cells has not been critically examined. To address this, we investigated platelet interactions in a range of ovarian cancer ... -
A polymorphism in the MTHFD1 gene increases a mother's risk of having an unexplained second trimester pregnancy loss.
(Oxford University Press, 2005)Low maternal folate or vitamin B12 status has been implicated in numerous pregnancy complications including spontaneous abortion. The primary aim of this study was to test a polymorphism within the trifunctional folate ... -
A polymorphism, R653Q, in the trifunctional enzyme methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase/formyltetrahydrofolate synthetase is a maternal genetic risk factor for neural tube defects: report of the Birth Defects Research Group
(2002)Women who take folic acid periconceptionally reduce their risk of having a child with a neural tube defect (NTD) by >50%. A variant form of methylenetetrahydrofolate reductase (MTHFR) (677C?T) is a known risk factor for ... -
Polyunsaturated fatty acids, macrophages, and mediators of atherosclerosis: an in vitro investigation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2004)Many cells are involved in the atherosclerotic process, but macrophages are present inevery phase of atherosclerosis and are heavily implicated as prime culprits in the molecular events that initiate, promote and complicate ... -
Population red blood cell folate concentrations for prevention of neural tube defects: bayesian model
(2014)OBJECTIVE: To determine an optimal population red blood cell (RBC) folate concentration for the prevention of neural tube birth defects. DESIGN: Bayesian model. SETTING: Data from two population based studies ... -
Post operative atrial fibrillation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2006)Post operative atrial fibrillation is a common occurrence following all forms of cardiac surgery apart from heart transplantation. Coronary artery bypass is the commonest cardiac surgical procedure with more than 800,000 ... -
Post-operative infection and sepsis in humans is associated with deficient gene expression of Yc cytokines and their apoptosis mediators.
(2011)INTRODUCTION: Lymphocyte homeostasis is dependent on the ?c cytokines. We hypothesised that sepsis in humans is associated with differential gene expression of the ?c cytokines and their associated apoptosis mediators. ... -
Post-polio Syndrome: More Than Just a Lower Motor Neuron Disease
(2019)Post-polio syndrome (PPS) is a neurological condition that affects polio survivors decades after their initial infection. Despite its high prevalence, the etiology of PPS remains elusive, mechanisms of progression are ... -
Postal questionnaire survey: the use of sleeping with the head of the bed tilted upright for treatment of orthostatic hypotension in clinical practice.
(2006)Orthostatic hypotension (OH) is common and affects one in five community-living older persons [1]. The incidence is higher amongst older in-patients [2] and those attending a syncope clinic [3]. The treatment of OH is ... -
Postprandial Cardiometabolic risk in Autoimmune Thyroid Disease and Type 1 Diabetes Mellitus
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2019)Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide. Atherosclerosis is implicated in the development of CVD. Postprandial lipaemia is independently predictive of atherogenesis and of ... -
Postprandial effect of dietary fat quantity and quality on arterial stiffness and wave reflection: a randomised controlled trial.
(2013)BACKGROUND: Arterial stiffness is a component of vascular function and an established risk factor for cardiovascular disease. There is a lack of conclusive evidence on the effect of a meal rich in monounsaturated fat ... -
Postprandial lipoprotein metabolism in diabetes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2001)Cardiovascular disease is up to four times greater in patients with Type 2 diabetes compared with nonnoglycaemic individuals (Pyorala et al., 1987; Laakso and Lehto 1997). Abnormalities in lipid metabolism may, in part, ...