Browsing Clinical Medicine by Title
Now showing items 799-818 of 949
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Single or double headed capsules for the investigation of suspected small bowel bleeding: Are two heads better than one.
(2022)Background: Capsule endoscopy is now the accepted first line investigation for suspected small bowel (SB) bleeding. Recent evidence suggests the diagnostic yield for SB pathology may be higher for tailored double headed ... -
siRNA Library Screening Identifies a Druggable Immune-Signature Driving Esophageal Adenocarcinoma Cell Growth
(2018)This study de fi nes immune-associated factors supportive of esophageal adenocarcinoma cell growth through small interfering RNA screening and pathologic and functional studies. Fostamatinib R788, targeting Janus ... -
siRNA silencing of the mutant keratin 12 allele in corneal limbal epithelial cells grown from patients with Meesmann's epithelial corneal dystrophy.
(2014)Purpose. The aim of this study is to further assess our previously reported keratin 12 (K12)-Leu132Pro specific siRNA in silencing the mutant allele in Meesmann's Epithelial Corneal Dystrophy (MECD) in experimental systems ... -
Sizing up the Next Generation of Nanomedicines
(2019)During the past two decades the nanomedicine field has experienced significant progress. To date, over sixty nanoparticle (NP) formulations have been approved in the US and EU while many others are in clinical or preclinical ... -
Skin barrier dysfunction measured by transepidermal water loss at 2 days and 2 months predates and predicts atopic dermatitis at 1 year.
(2015)Loss-of-function mutations in the skin barrier protein filaggrin (FLG) are a major risk for atopic dermatitis (AD). The pathogenic sequence of disturbances in skin barrier function before or during the early development ... -
Skin barrier impairment at birth predicts food allergy at 2 years of age.
(2016)Background Transcutaneous exposure to food allergens can lead to food sensitisation (FS)/food allergy (FA). We measured skin barrier function in early infancy and related it to the later development of FS/FA at 2 ... -
Sleeping with the head [up] of the bed tilted up: physiology & therapy
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)Orthostatic hypotension (OH) is common and affects people with increasing age and co-morbidity. It is associated with increased vascular risk, falls and dementia. While pharmacological and non-pharmacological treatments ... -
Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2022.
(2023)This Guideline is an official statement from the European Society of Gastrointestinal Endoscopy (ESGE). It is an update of the previously published 2015 ESGE Clinical Guideline addressing the role of small-bowel ... -
SOCS2 regulates T helper type 2 differentiation and the generation of type 2 allergic responses.
(2011)The incidence of allergy and asthma in developed countries is on the increase and this trend looks likely to continue. CD4+ T helper 2 (Th2) cells are major drivers of these diseases and their commitment is controlled by ... -
Specialist palliative for patients with cancer: more than end-of-life care
(2023)Palliative care has traditionally focused on end-of-life care for patients with advanced cancer. This has since expanded to include symptom management and quality-of-life improvement from the moment of cancer diagnosis. ... -
Specific intracellular adhesion molecule-grabbing nonintegrin R1 is not involved in the murine antibody response to pneumococcal polysaccharides.
(American Society for Microbiology, 2007)treptococcus pneumoniae is a microorganism that frequently causes serious infections in children, the elderly, and immunocompromised patients. We studied whether the specific intracellular adhesion molecule-grabbing ... -
The spectrum of impulse control behaviours in Parkinson's disease: pathophysiology and management
(2020)Impulse control behaviours (ICBs) are a range of behaviours linked by their reward-based, repetitive natures. They can be precipitated in Parkinson’s Disease (PD) by dopamine replacement therapy, often with detrimental ... -
Sphingosine-1-phosphate receptor modulator FTY720 attenuates experimental myeloperoxidase-ANCA vasculitis in a T cell-dependent manner
(2020)Sphingosine-1-phosphate (S1P) is a pleiotropic lysosphingolipid derived from the metabolism of plasma membrane lipids. The interaction between S1P and its ubiquitously expressed G-protein-coupled receptors (S1PR1-5) is ... -
Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity.
(2015)Atopic dermatitis (AD) is an inflammatory skin condition that can occur in early life, predisposing to asthma development in a phenomenon known as the atopic march. Although genetic and environmental factors are known to ... -
Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity.
(2015)Atopic dermatitis (AD) is an inflammatory skin condition that can occur in early life, predisposing to asthma development in a phenomenon known as the atopic march. Although genetic and environmental factors are known to ...