Browsing Clinical Medicine by Title
Now showing items 819-838 of 949
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Stand Up, Speak Out! Racial Justice in Healthcare Education: Experiences of Minoritised Ethnic Students
(TCD, 2022)Funded by Trinity Equality Fund 2022, the Faculty of Health Sciences Equality, Diversity and Inclusion (EDI) Group and Immigrant Council of Ireland launched a project entitled ‘Stand Up, Speak Out! Racial Justice in ... -
STAT3 knockdown by siRNA induces apoptosis in human cutaneous T-cell lymphoma line Hut78 via downregulation of Bcl-xL
(2010)Cutaneous T-cell lymphomas (CTCLs) are non-Hodgkin's lymphomas resulting from clonal expansion and localization of malignant T-lymphocytes to the skin. CTCL cells have defective ... -
Sterile inflammation - do innate lymphoid cell subsets play a role?
(2012)The recent identification of several novel innate lymphoid cell (iLC) subsets has increased our understanding of the mechanisms which link the innate and adaptive immune systems. While the contribution of these subsets ... -
Steroid resistance and Inflammatory bowel disease
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Background: Steroid resistance remains a significant issue amongst IBD patients and mechanisms of resistance remain poorly understood. Endogenous Glucocorticoid metabolism may represent a key regulatory pathway in IBD. ... -
Strategies for the purification of membrane proteins
(Springer, 2011)Although membrane proteins account for 20–30% of the coding regions of all sequenced genomes and play crucial roles in many fundamental cell processes, there are relatively few membranes with known 3D structure. This is ... -
Stratification of amyotrophic lateral sclerosis patients: A crowdsourcing approach
(2019)Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease where substantial heterogeneity in clinical presentation urgently requires a better stratification of patients for the development of drug trials and ... -
Stroke and Nursing Home Care: a national survey of nursing homes.
(2010)BACKGROUND: Although stroke is recognised as a major factor in admission to nursing home care, data is lacking on the extent and nature of the disabilities and dependency in nursing homes arising from stroke. A national ... -
A structural analysis of DNA binding by hSSB1 (NABP2/OBFC2B) in solution
(2016)Single-stranded DNA binding proteins (SSBs) play an important role in DNA processing events such as replication, recombination and re- pair. Human single-stranded DNA binding pro- tein ... -
Studies on methotrexate cytotoxicity and apoptosis in human B-lymphocyte cell lines : with emphasis on 5,10-methylenetetrahydrofolate reductase 677C→T genotype and folate status
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2011)Methotrexate (Mtx) is an antifolate drug which is widely used in treatment of cancer and of autoimmune and inflammatory conditions. The main mechanism by which Mtx operates is inhibition of dihydrofolate reductase (DHFR), ... -
Studies on the interaction of Helicobacter pylori with extracellular matrix proteins
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)Helicobacter pylori is a common human pathogen that persistently colonises the stomach of half the worlds population. The majority of people infected with H. pylori are asymptomatic, however, a proportion develop severe ... -
Study of Macular Pigments in Glaucoma
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)The macula can be involved in the early stage of glaucoma, as evidenced by the presence of paracentral scotoma on visual field tests (Drance 1969) or thinning of the ganglion cell complex (GCC) layer on optical coherence ... -
A study of the clinical impact and outcomes of pharmacist-led interventions in the outpatient model of care for Hepatitis C patients in Ireland and their development into a novel complex intervention toolkit
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Given the high rates of sustained virological response and good tolerability of direct-acting antiviral regimens, international guidelines now recommend that all Hepatitis C infected patients be considered for access to ... -
Study Protocol for DeCOmPRESS: Defining the Disease Course and Immune Profile of COVID-19 in the Immunosuppressed Patient
(2021)The ongoing coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Current advisory guidelines for high-risk groups—including people with autoimmune disease ... -
Successful treatment of florid cutaneous warts with intravenous cidofovir in an 11-year-old girl.
(2008)Cutaneous warts, commonly seen in children and the immunosuppressed are socially distressing and are often resistant to traditional treatments. Here, we report an 11-year-old girl with bilateral florid verrucous lesions ... -
Supportive care: the "keystone" of modern oncology practice
(2023)The Multinational Association of Supportive Care in Cancer (MASCC) defines supportive care as "the prevention and management of the adverse effects of cancer and its treatment. This includes management of physical and ... -
Surface layer proteins isolated from Clostridium difficile induce clearance responses in macrophages
(2014)Clostridium difficile is the leading cause of hospital-acquired diarrhoea worldwide, and if the bacterium is not cleared effectively it can pose a risk of recurrent infections and complications such as colitis, sepsis and ... -
Surface layer proteins of Clostridium difficile as novel vaccine candidates
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2005)Clostridium difficile is a major cause of antibiotic associated diarrhoea and pseudomembranous colitis in hospitalised patients. The major precipitating factor for C. difficile-associated disease (CDAD) is disruption of ... -
Survival Analysis of Irish Amyotrophic Lateral Sclerosis Patients Diagnosed from 1995 2010
(2013)Introduction: The Irish ALS register is a valuable resource for examining survival factors in Irish ALS patients. Cox regression has become the default tool for survival analysis, but recently new classes of flexible ... -
Survival prediction in Amyotrophic lateral sclerosis based on MRI measures and clinical characteristics
(2017)Background: Amyotrophic lateral sclerosis (ALS) a highly heterogeneous neurodegenerative condition. Accurate diagnostic, monitoring and prognostic biomarkers are urgently needed both for individualised patient care and ...