School of Pharmacy and Pharmaceutical Sciences
Academic/Research Units within this Academic/Research Unit
-
Pharmaceutical Chemistry
Pharmaceutical Chemistry -
Pharmaceutics & Pharmaceutical Technology
Pharmaceutics & Pharmaceutical Technology -
Pharmacognosy
Pharmacognosy -
Pharmacology
Pharmacology -
Pharmacy and Pharmaceutical Sciences
Pharmacy and Pharmaceutical Sciences
Recent Submissions
-
Using in vitro and in silico approaches to investigate ibuprofen particulate and formulation dissolution behaviour under different hydrodynamic conditions.
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2024)This work investigated the effect of fluid velocity and medium viscosity on the dissolution of ibuprofen powder and ibuprofen immediate release tablets in vitro, in the paddle apparatus and the flow-through apparatus, and ... -
The treatment of obesity using magneto -mechanical effect
Obesity is a very prevalent condition that can be very often associated with the development of comorbidities, such as insulin resistance, hypertension, and hyperlipidaemia that can lead to cardiovascular and cerebrovascular ... -
A mixed-methods approach to explore the association between age and medication -related problems among adults
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2024)General introduction Much attention was focused on the ageing phenomenon and how to improve the quality of life in older people. Medication-related problems (MRPs) can potentially lead to hospital admissions, increased ... -
Chemotherapy drug scheduling for the induction treatment of patients with acute myeloid leukemia
(2014)Leukemia is an immediately life-threatening cancer wherein immature blood cells are overproduced, accumulate in the bone marrow (BM) and blood and causes immune and blood system failure. Treatment with chemotherapy can ... -
Long-term cytokine-free expansion of cord blood mononuclear cells in three-dimensional scaffolds
(2011)Cord blood expansion ex vivo can be achieved in liquid suspension through the addition of cytokines at the expense of often undesirable cell differentiation. In order to derive a cytokine-free dynamic culture system, we ... -
The development of a three-dimensional scaffold for ex vivo biomimicry of human acute myeloid leukaemia
(2010)Acute myeloid leukaemia (AML) is a cancer of haematopoietic cells that develops in three-dimensional (3-D) bone marrow niches in vivo. The study of AML has been hampered by lack of appropriate ex vivo models that mimic ... -
Development and preliminary evaluation of OPTI-3S: A deprescribing support tool for hospitalised frail older adults.
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2024)Introduction: In frail older people, polypharmacy (5 or more regular prescribed medicines) and the prescription of potentially inappropriate medicines (PIMs) are known to be prevalent and linked to negative clinical outcomes. ... -
Dynamic human erythropoiesis in a three-dimensional perfusion bone marrow biomimicry
(2019)Traditional culture systems for human erythropoiesis lack microenvironmental niches, spatial marrow gradients and dense cellularity rendering them incapable of effectively translating marrow physiology ex vivo. Herein, a ... -
Mesoporous Silica Nanocarriers for triggered drug delivery in the treatment of cancer
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2023)Cancer is the second leading cause of death globally, accounting for 10 million deaths in 2020. Cancer chemotherapy is currently limited by a high systemic toxicity that occurs as a result of high systemic dosing and the ... -
A theory-based exploration of the medicines management process provided to older people residing in the nursing home setting in the Republic of Ireland
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2023)Introduction While the population is ageing globally, this does not necessarily mean that they are living healthier. The multimorbidity and polypharmacy in the older population (age> 65 years) increases their risk of ... -
What is a prescription?
(2007) -
Deprescribing Falls Risk Increasing Drugs in Older Adults
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2023)Aim: The purpose of this thesis was to examine the facilitators of, and barriers to, implementing deprescribing of falls risk increasing medicines (FRIDs) in healthcare professionals' practices, by exploring the perspectives ... -
Deciphering the interplay of extracellular vesicles and drug resistance in HER2-positive breast cancer: insights, biomarkers and therapeutic implications
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2023)According to a World Health Organisation (WHO) report on 3rd March 2021, breast cancer is the most common form of cancer in the world and the leading cause of cancer death among females. In 2020, 2.26 million newly breast ... -
Approaches to Drying Hydrated Active Pharmaceutical Ingredients (APIs).
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2023)This project aims to develop a drying protocol that removes unwanted moisture from hydrated APIs while preserving water of hydration. Hydrate forms of model compounds, carbamazepine and theophylline, were generated with ... -
Milking extracellular vesicles for health benefit using a multi-omics approach
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2023)Milk is remarkable source of nutrients (i.e., proteins, fat, and sugars) and extracellular vesicles (EVs). EVs are tiny vesicles release by cells into all biofluids including milk. Milk EVs have been gathered huge attention ...