Browsing by Author "REYNOLDS, JOHN"
Now showing items 1-20 of 38
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A Barrett's esophagus registry of over 1000 patients from a specialist center highlights greater risk of progression than population-based registries and high risk of low grade dysplasia.
REYNOLDS, JOHN; O'SULLIVAN, JACINTHA; RAVI, NARAYANASAMY (2015) -
Cancer Cachexia:Mechanisms and Clinical Implications
REYNOLDS, JOHN; DONOHOE, CLAIRE (Hindawi, 2011)Cachexia is amultifactorial process of skeletal muscle and adipose tissue atrophy resulting in progressive weight loss. It is associated with poor quality of life, poor physical function, and poor prognosis in cancer ... -
The characterization of an intestine-like genomic signature maintained during Barrett's-associated adenocarcinogenesis reveals an NR5A2-mediated promotion of cancer cell survival
SENGE, MATHIAS; REYNOLDS, JOHN (2016)Barrett’s oesophagus (BO), an intestinal-type metaplasia (IM), typically arising in conjunction with gastro-oesophageal reflux disease, is a prominent risk factor for the development of oesophageal adenocarcinoma (OAC). ... -
Common data items in seven European oesophagogastric cancer surgery registries: Towards a European Upper GI Cancer Audit (EURECCA Upper GI)
REYNOLDS, JOHN (2014)Aims Seven countries (Denmark, France, Ireland, the Netherlands, Poland, Sweden, United Kingdom) collaborated to initiate a EURECCA (European Registration of Cancer Care) Upper GI project. The aim of this study was to ... -
COX-Derived prostanoid pathways in gastrointestinal cancer development and progression: Novel targets for prevention and intervention
REYNOLDS, JOHN; O'SULLIVAN, JACINTHA; CATHCART, MARY CLARE; PIDGEON, GRAHAM; O'BYRNE, KEN (Elsevier, 2012)Arachidonic acid metabolism through cyclooxygenase (COX) pathways leads to the generation of biologically active eicosanoids. Eicosanoid expression levels vary during development and progression of gastrointestinal (GI) ... -
Defining a successful esophagectomy.
REYNOLDS, JOHN (2014) -
Deoxycholic acid promotes development of gastroesophageal reflux disease and Barrett's oesophagus by modulating integrin-??v trafficking
FINN, STEPHEN; O'SULLIVAN, JACINTHA; LONG, AIDEEN; BYRNE, ANNE-MARIE; REYNOLDS, JOHN (2017) -
Differential expression of mitochondrial energy metabolism profiles across the metaplasia-dysplasia-adenocarcinoma disease sequence in Barrett's oesophagus.
RAVI, NARAYANASAMY; O'SULLIVAN, JACINTHA; REYNOLDS, JOHN; LYNAM-LENNON, NIAMH (2014) -
Diffuse oesophageal leiomyomatosis.
FINN, STEPHEN; REYNOLDS, JOHN; MULDOON, CIAN; RAVI, NARAYANASAMY (2013) -
Dissecting intramural hematoma of the esophagus.
REYNOLDS, JOHN (2013) -
Elevated Tumor Expression of PAI-1 and SNAI2 in Obese Esophageal Adenocarcinoma Patients and Impact on Prognosis.
LYSAGHT, JOANNE; REYNOLDS, JOHN; PIDGEON, GRAHAM (2012) -
The esophagitis to adenocarcinoma sequence; the role of inflammation.
REYNOLDS, JOHN (2014) -
Golgi phosphoprotein 2 (GOLPH2) is a novel bile acid-responsive modulator of oesophageal cell migration and invasion
BYRNE, ANNE-MARIE; FINN, STEPHEN; REYNOLDS, JOHN; LONG, AIDEEN (2015)Background: The aetiology of Barrett’s oesophagus (BO) and oesophageal cancer is poorly understood. We previously demonstrated that Golgi structure and function is altered in oesophageal cancer cells. A Golgi-associated ... -
HLA-DR expression in tumor epithelium is an independent prognostic indicator in esophageal adenocarcinoma patients
Dunne, Margaret; REYNOLDS, JOHN; RAVI, NARAYANASAMY (2017) -
ICORG 10-14: NEOadjuvant trial in Adenocarcinoma of the oEsophagus and oesophagoGastric junction International Study (Neo-AEGIS)
REYNOLDS, JOHN; RAVI, NARAYANASAMY (2017) -
Images in clinical medicine. Intermittent facial flushing and diarrhea.
REYNOLDS, JOHN (2014) -
Internal hernia following total gastrectomy with Roux-en-Y reconstruction.
REYNOLDS, JOHN; RAVI, NARAYANASAMY (2011)Internal herniation is a well-described complication after a gastric bypass, particularly when performed laparoscopically, although it is rarely described following a total gastrectomy. A 55-year-old lady presented with ... -
LC3B globular structures correlate with survival in esophageal adenocarcinoma
O'SULLIVAN, JACINTHA; REYNOLDS, JOHN (2015)Background Esophageal adenocarcinoma has the fastest growing incidence of any solid tumor in the Western world. Prognosis remains poor with overall five-year survival rates under 25 %. Only a limited number of patients ... -
Long-term activation of the pro-coagulant response after neoadjuvant chemoradiation and major cancer surgery.
PIDGEON, GRAHAM; REYNOLDS, JOHN; MAHER, STEPHEN; WHITE, BARRY; O'DONNELL, JAMES (2010)Background: The association between cancer, major surgery and venous thromboembolism (VTE) is well established. Multimodal therapy is increasingly being used as standard treatment for localised gastrointestinal ... -
Low pH results in co-ordinate regulation of gene expression in oesophageal cells
KELLEHER, DERMOT P; REYNOLDS, JOHN; DUGGAN, SHANE (2006)