Browsing by Author "Berney, Mark"

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    • Development of modified nucleosides for targeting the DNA repair enzyme SNM1A 

      Berney, Mark (Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2022)
      Certain cancers exhibit upregulation of DNA interstrand crosslink repair pathways, which contributes to resistance to crosslinking chemotherapy drugs and poor prognoses. Inhibition of enzymes implicated in interstrand ...

    • Methods for detection of cytosine and thymine modifications in DNA 

      McGouran, Joanna; Berney, Mark (2018)
      Methylation of cytosine at the 5-position is a common epigenetic modification in mammalian DNA and plays an important role in regulating gene expression. Oxidized derivatives of 5-methylcytosine were discovered recently, ...