Browsing by Author "Coleman, David"
Now showing items 1-19 of 19
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AZOLE SUSCEPTIBILITY AND RESISTANCE IN CANDIDA DUBLINIENSIS
Sullivan, Derek; Coleman, David; Moran, Gary (2005)Candida dubliniensis is a recently described species of pathogenic yeast that shares many phenotypic features with Candida albicans. It is primarily associated with oral colonization and infection in HIV-infected individuals. ... -
COMPARATIVE TRANSCRIPT PROFILING OF Candida albicans AND Candida dubliniensis IDENTIFIES SFL2, A C. albicans GENE REQUIRED FOR VIRULENCE IN A RECONSTITUTED EPITHELIAL INFECTION MODEL
Sullivan, Derek; Coleman, David; Moran, Gary (2010)Candida albicans and Candida dubliniensis are closely related species displaying differences in virulence and genome content, therefore providing potential opportunities to identify novel C. albicans virulence genes. C. ... -
Contribution of whole-genome sequencing to understanding of the epidemiology and control of meticillin-resistant Staphylococcus aureus
Coleman, David; Humphreys, Hilary (2019)In recent years, approaches to tracking the spread of meticillin-resistant Staphylococcus aureus (MRSA) as part of outbreak management have used conventional DNA-based methods, including pulsed-field gel electrophoresis ... -
EFFECTIVE CLEANING AND DECONTAMINATION OF THE INTERNAL AIR AND WATER CHANNELS, HEADS AND HEAD-GEARS OF MULTIPLE CONTRA ANGLE DENTAL HANDPIECES USING AN ENZYMATIC DETERGENT AND AUTOMATED WASHER DISINFECTION IN A DENTAL HOSPITAL SETTING
Coleman, David; Deasy, Emily; O'Donnell, Mary (2022)Background Dental handpieces (DHPs) are reusable invasive medical devices that must be cleaned, decontaminated, lubricated and steam sterilized after use. DHPs have a complex internal design including narrow channels, ... -
ELIMINATION OF BIOFILM AND MICROBIAL CONTAMINATION RESERVOIRS IN HOSPITAL WASHBASIN U-BENDS BY AUTOMATED CLEANING AND DISINFECTION WITH ELECTROCHEMICALLY ACTIVATED SOLUTIONS
Coleman, David; O'Donnell, Mary; Deasy, Emily; Russell, Ronald (2016) -
AN EMERGING PANTON-VALENTINE (PVL)-POSITIVE CC5-METICILLIN-RESISTANT Staphylococcus aureus-IVc CLONE RECEOVERED FROM HOSPITAL AND COMMUNITY SETTINGS OVER A 17-YEAR PERIOD FROM 12 COUNTRIES INVESTIGATED BY WHOLE-GENOME SEQUENCING
Coleman, David; Kinnevey, Peter (2023)Background A novel Panton–Valentine leukocidin (PVL)-positive meticillin-resistant Staphylococcus aureus (MRSA) clonal complex (CC)5-MRSA-IVc (‘Sri Lankan’ clone) was recently described from Sri Lanka. Similar isolates ... -
FIRST DESCRIPTION OF ARGININE CATABOLIC MOVILE ELEMENT (ACME) TYPE VI HARBORING THE kdp OPERON ONLY IN Staphylococcus epidermidis USING SHORT AND LONG READ WHOLE GENOME SEQUENCING: FURTHER EVIDENCE OF ACME DIVERSITY
Coleman, David; Mc Manus, Brenda (2019)The arginine catabolic mobile element (ACME) was first described in methicillin-resistant Staphylococcus aureus and is considered to enhance transmission, persistence and survival. Subsequently ACMEs were shown to be more ... -
Genome-wide gene expression profiling and a forward genetic screen show that differential expression of the sodium ion transporter Ena21 contributes to the differential tolerance of Candida albicans and Candida dubliniensis to osmotic stress
Enjalbert, Brice; Moran, Gary; Vaughan, Claire; Yeomans, Tim; MacCallum, Donna; Quinn, Janet; Coleman, David; Brown, Alistair; SULLIVAN, DEREK (Wiley-Blackwell, 2009)Candida albicans is more pathogenic than Candida dubliniensis. However, this disparity in virulence is surprising given the high level of sequence conservation and the wide range of phenotypic traits shared by these two ... -
A HOSPITAL OUTBREAK OF LINEZOLID-RESISTANT AND VANCOMYCIN-RESISTANT Enterococcus faecium HARBOURING AN optrA-ENCODING CONJUGATIVE PLASMID INVESTIGATED BY WHOLE GENOME SEQUENCING
Coleman, David (2020)Background: Linezolid is an antibiotic used to treat infections caused by multi-drug-resistant Gram-positive bacteria. Linezolid resistance in enterococci has been reported with increasing frequency, with a recent rise in ... -
IMMERSION OF DEBRIDED DIABETIC FOOT ULCER (DFU) TISSUE IN ELECTROCHEMICALLY GENERATED PH NEUTRAL HYPOCHLOROUS ACID SIGNIFICANTLY REDUCES THE MICROBIAL BIOBURDEN: WHOLE-GENOME SEQUENCING OF Staphylococcus aureus, THE MOST PREVALENT SPECIES RECOVERED
Coleman, David; Daly, Blanaid; Dougall, Alison; Mc Manus, Brenda; Polyzois, Ioannis (2023)Background: Diabetic foot ulcer infections (DFUIs) are the leading cause of lower limb amputations, mediated predominantly by Staphylococcus aureus. pH neutral electrochemically-generated hypochlorous acid (anolyte) is a ... -
METICILLIN-RSISTANT Staphylococcus aureus TRANSMISSION AMONG HEALTHCARE WORKERS, PATIENTS AND THE ENVIRONMENT IN A LARGE ACUTE HOSPITAL UNDER NON-OUTBREAK CONDITIONS INVESTIGATED BY WHOLE-GENOME SEQUENCING
Coleman, David; Kearney, Aoife; Kinnevey, Peter (2021)Background: The role of meticillin-resistant Staphylococcus aureus (MRSA) colonization of healthcare workers (HCWs), patients and the hospital environment in MRSA transmission in non-outbreak settings is poorly understood. Aims: ... -
Meticillin-susceptible Staphylococcus aureus transmission among healthcare workers, patients and the environment in a large acute hospital under non-outbreak conditions investigated using whole-genome sequencing
Coleman, David; Kinnevey, Peter (2022)Background: The role of meticillin-susceptible Staphylococcus aureus (MSSA) colonization of healthcare workers (HCWs), patients and the hospital environment in MSSA transmission events (TEs) is poorly understood. Aims: ... -
MINIMIZING MICROBIAL CONTAMINATION RISK SIMULTANEOUSLY FROM MULTIPLE HOSPITAL WASHBASINS BY AUTOMATED CLEANING AND DISINFECTION OF U-BENDS WITH ELECTROCHEMICALLY ACTIVATED SOLUTIONS
Coleman, David; O'Donnell, Mary; Deasy, Emily (2018) -
MULTIPLE DISTINCT OUTBREAKS OF PANTON-VALENTINE LEUKOCIDIN (PVL)-POSITIVE COMMUNITY-ASSOCIATED METHICILLIN-RESISTANT Staphylococcus aureus (CA-MRSA) IN IRELAND INVESTIGATED BY WHOLE-GENOME SEQUENCING
Coleman, David; Mc Manus, Brenda (2021)Background: Panton–Valentine leucocidin (PVL)-positive community-associated meticillin-resistant Staphylococcus aureus (CA-MRSA) is increasingly associated with infection outbreaks. Aim: To investigate multiple suspected ... -
A novel multidrug-resistant PVL-negative CC1-MRSA-1 IV clone emerging in Ireland and Germany likely originated in South-Eastern Europe
Coleman, David; Shore, Anna; Earls, Megan R.; Brennan, Gráinne I.; Simbeck, Alexandra; Schneider-Brachert, Wulf; Vremerǎ, Teodora; Dorneanu, Olivia S.; Slickers, Peter; Ehricht, Ralf; Monecke, Stefan; Coleman, David C. (2019)This study investigated the recent emergence of multidrug-resistant Panton-Valentine leukocidin (PVL)-negative CC1-MRSA-IV in Ireland and Germany. Ten CC1-MSSA and 139 CC1-MRSA isolates recovered in Ireland between 2004 ... -
OVERCOMING THE PROBLEM OF RESIDUAL MICROBIAL CONTAMINATION IN DENTAL SUCTION UNITS LEFT BY CONVENTIONAL DISINFECTION USING NOVEL SINGLE COMPONENT SUCTION HANDPIECES IN COMBINATION WITH AUTOMATED FLOOD DISINFECTION
Coleman, David; O'Donnell, Mary; Russell, Ronald (2015) -
SIGNIFICANT ENRICHMENT AND DIVERSITY OF THE STAPHYLOCOCCAL ARGININE CATABOLIC MOBILE ELEMENT ACME IN STAPHYLOCOCCUS EPIDERMIDIS ISOLATES FROM SUBGINGIVAL PERI-IMPLANTITIS SITES AND PERIODONTAL POCKETS
Mc Manus, Brenda; Coleman, David; O'Sullivan, Michael; Kinnevey, Peter (2018) -
Whole-genome sequencing identifies highly related Pseudomonas aeruginosa strains in multiple washbasin U-bends at several locations in one hospital: evidence for trafficking of potential pathogens via wastewater pipes
Coleman, David; O'Donnell, Mary; Moloney, E.M.; Deasy, Emily; Swan, James S.; Brennan, Gráinne I. (2020)Background: Hand washbasin U-bends have increasingly been associated with nosocomial outbreaks by Gram-negative bacteria, including Pseudomonas aeruginosa which is virtually ubiquitous in U-bends. Wastewater networks ...