Browsing by Author "Conroy, Melissa"
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Acidosis significantly alters immune checkpoint expression profiles of T cells from oesophageal adenocarcinoma patients
Lysaght, Joanne; Ravi, Narayanasamy; Reynolds, John; Conroy, Melissa (2023)Tumour acidosis contributes to cancer progression by inhibiting anti-tumour immunity. However, the effect of acidosis on anti-tumour T cell phenotypes in oesophageal adenocarcinoma (OAC) is unknown. Therefore, this study ... -
Analysing the Combined Effects of Radiotherapy and Chemokine Receptor 5 Antagonism: Complementary Approaches to Promote T Cell Function and Migration in Oesophageal Adenocarcinoma.
Conroy, Melissa (2024)The presence of an immunosuppressive tumour microenvironment in oesophageal adenocarcinoma (OAC) is a major contributor to poor responses. Novel treatment strategies are required to supplement current regimens and improve ... -
Characterisation of the effects of pulsed radio frequency treatment of the dorsal root ganglion on cerebrospinal fluid cellular and peptide constituents in patients with chronic radicular pain: a randomised, triple-blinded controlled trial
Conroy, Melissa (2020)Introduction: Chronic radicular neuropathic pain is a major clinical problem with a life time prevalence of more than 50%. Pulsed radiofrequency (PRF) treatment is a recognised therapy. However, the pathophysiology of ... -
Chemokine-targeted therapies: An opportunity to remodel immune profiles in gastro-oesophageal tumours
Conroy, Melissa (2021)Immunotherapies are transforming outcomes for many cancer patients and are quickly becoming the fourth pillar of cancer therapy. However, their efficacy of only ∼25% in gastro-oesophageal cancer has been disappointing. ... -
Examination and characterisation of burst spinal cord stimulation on cerebrospinal fluid cellular and protein constituents in patient responders with chronic neuropathic pain - A Pilot Study
Conroy, Melissa (2020)Introduction: Patients with neuropathic pain have altered proteomic and neuropeptide constituents in cerebrospinal fluid (CSF) compared to controls. Tonic spinal cord stimulation (SCS) has demonstrated differential expression ... -
Examination and characterisation of the effect of amitriptyline therapy for chronic neuropathic pain on neuropeptide and proteomic constituents of human cerebrospinal fluid.
Conroy, Melissa (2020)Introduction: Amitriptyline is prescribed to reduce the intensity of chronic neuropathic pain. There is a paucity of validated in vivo evidence in humans regarding amitriptyline's mechanism of action. We examined the effect ... -
Existing evidence for the repurposing of PARP-1 inhibitors in rare demyelinating diseases
Dev, Kumlesh; Conroy, Melissa (2022)Over the past decade, Poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors have arisen as a novel and promising targeted therapy for breast cancer gene (BRCA)-mutated ovarian and breast cancer patients. Therapies targeting ... -
Fractalkine Elicits Chemotactic, Phenotypic, and Functional Effects on CX3CR1+ CD272 NK Cells in Obesity-Associated Cancer
Lysaght, Joanne; Conroy, Melissa (2021)Esophagogastric adenocarcinomas (EAC) are obesity-associated malignancies underpinned by severe immune dysregulation and inflammation. Our previous work indicates that NK cells migrate to EAC omentum, where they undergo ... -
Harnessing Natural Killer Cells in Non-small Cell Lung Cancer
Conroy, Melissa (2022)Lung cancer is the leading cause of cancer-related deaths worldwide. There are two main subtypes: small cell lung cancer (SCLC), and non-small cell lung cancer (NSCLC). NSCLC accounts for 85% of lung cancer diagnoses. Early ... -
The impact of Esophageal Oncological Surgery on perioperative immune function; implications for adjuvant immune checkpoint inhibition
Conroy, Melissa (2022)Background: Immune checkpoint inhibitors (ICIs) are being investigated for their role as an adjunct in the multimodal treatment of esophageal adenocarcinoma (EAC). The most effective time to incorporate ICIs remains ... -
Incidence and Impact of Non-alcoholic Fatty Liver Disease (NAFLD) in Patients with Adenocarcinoma of the Esophagus Treated with Curative Intent
Lysaght, Joanne; Ravi, Narayanasamy; Reynolds, John; Elliott, Jessie; Conroy, Melissa (2022)Background and aims: Esophageal adenocarcinoma (EAC) is associated with visceral obesity (VO). Non-alcoholic fatty liver disease (NAFLD) is common within this phenotype; however, its incidence and clinical significance in ... -
Investigating the Effects of Olaparib on the Susceptibility of Glioblastoma Multiforme Tumour Cells to Natural Killer Cell-Mediated Responses
Lysaght, Joanne; Conroy, Melissa (2023)Glioblastoma multiforme (GBM) is the most common adult primary brain malignancy, with dismal survival rates of ~14.6 months. The current standard-of-care consists of surgical resection and chemoradiotherapy, however the ... -
Investigating the susceptibility of treatment-resistant oesophageal tumours to natural killer cell-mediated responses
Maher, Stephen; Reynolds, John; Conroy, Melissa (2023)The majority of oesophageal adenocarcinoma (OAC) patients do not respond to multimodal treatment regimens and face dismal survival rates. Natural killer (NK) cells are crucial anti-tumour immune cells, and this study ... -
Natural killer cell therapy: A new frontier for obesity-associated cancer
Lysaght, Joanne; Conroy, Melissa (2022)Natural killer (NK) cell infiltration of solid tumours is associated with better outcomes, placing augmentation of NK cell abundance in tumours as an attractive immunotherapeutic approach. The unique ability of NK cells ... -
The Omentum in Obesity-Associated Cancer: A Hindrance to Effective Natural Killer Cell Migration towards Tumour Which Can Be Overcome by CX3CR1 Antagonism
Lysaght, Joanne; Conroy, Melissa (2021)Oesophagogastric adenocarcinomas (OAC) are obesity-associated malignancies, underpinned by severe immune dysregulation. We have previously shown that natural killer (NK) cells preferentially migrate to OAC omentum, where ... -
A Study of the Immune Infiltrate and Patient Outcomes in Esophageal Cancer.
Conroy, Melissa (2020)Objectives: Cancer patient outcomes and selection for novel therapies are heavily influenced by the immune contexture of the tumor microenvironment. Esophageal cancer is associated with poor outcomes. In contrast to ... -
Tissue distribution of ?? T cell subsets in oesophageal adenocarcinoma
Conroy, Melissa (2021)The global obesity epidemic is contributing to increased prevalence of diseases fuelled by chronic inflammation, including cancer. Oesophageal adenocarcinoma (OAC) is an obesity-associated malignancy with increasing ...