Browsing by Author "Corvin, Aiden"
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A molecular genetic investigation of schizophrenia in an Irish study population
Corvin, Aiden (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2006)Schizophrenia (OMIM 181500) is a complex genetic disorder, which affects ~1% of the population, and typically presents in early adulthood with abnormalities of perception (psychosis), cognition, information processing and ... -
Biological insights from 108 schizophrenia-associated genetic loci.
Gill, Michael; Donohoe, Gary; Corvin, Aiden (2014) -
Common polygenic variation in coeliac disease and confirmation of ZNF335 and NIFA as disease susceptibility loci
Corvin, Aiden; Mc Manus, Ross; Kelleher, Dermot; Trimble, Valerie; Kennedy, Nicholas (2016)Coeliac disease (CD) is a chronic immune-mediated disease triggered by the ingestion of gluten. It has an estimated prevalence of approximately 1% in European populations. Specific HLA-DQA1 and HLA-DQB1 alleles are established ... -
Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium
Corvin, Aiden (2018)Background: The profile of cortical neuroanatomical abnormalities in schizophrenia is not fully understood, despite hundreds of published structural brain imaging studies. This study presents the first meta-analysis of ... -
Cortical patterning of abnormal morphometric similarity in psychosis is associated with brain expression of schizophrenia-related genes
Corvin, Aiden; Morgan, Sarah E.; Seidlitz, Jakob; Whitaker, Kirstie J.; Romero-Garcia, Rafael; Clifton, Nicholas E.; Scarpazza, Cristina; van Amelsvoort, Therese; Marcelis, Machteld; van Os, Jim; Mothersill, David; Pocklington, Andrew; Raznahan, Armin; McGuire, Philip; Vértes, Petra E.; Bullmore, Edward T. (2019)Despite significant research, the biological mechanisms underlying schizophrenia are still unclear. We shed light on structural brain differences in psychosis using an approach called morphometric similarity mapping, which ... -
Disrupted in schizophrenia 1 (DISC1) mutants have impaired activity-dependent plasticity in vitro and in vivo
Corvin, Aiden; Mitchell, Kevin (2016) -
Genetic correlation between amyotrophic lateral sclerosis and schizophrenia.
Mc Laughlin, Russell; Corvin, Aiden; Hardiman, Orla; Bradley, Daniel (2017)We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the ... -
Genome-wide schizophrenia variant at MIR137 does not impact white matter microstructure in healthy participants
Gill, Michael; Donohoe, Gary; Corvin, Aiden (2014) -
Moral cognition and homicide amongst forensic patients with schizophrenia and schizoaffective disorder: A cross-sectional cohort study
Corvin, Aiden; Kennedy, Harry (2018)Abstract Forensic patients with schizophrenia who had carried out a homicide scored higher on a measure of moral cognition (MFQ-30) than other violent patients. Neurocognitive impairment was associated with homicide by ... -
Prospective observational cohort study of 'treatment as usual' over four years for patients with schizophrenia in a national forensic hospital.
Kennedy, Harry; Corvin, Aiden; Davoren, Mary (2018)Background: We evaluated change in response to multi-modal psychosocial ‘treatment as usual’ programs offered within a forensic hospital. Methods: Sixty nine patients with a diagnosis of schizophrenia or schizoaffective ... -
A randomized controlled trial of cognitive remediation for a national cohort of forensic patients with schizophrenia or schizoaffective disorder
Corvin, Aiden; Kennedy, Harry (2019)Background: Evidence is accumulating that Cognitive Remediation Training (CRT) is effective for ameliorating cognitive deficits experienced by patients with schizophrenia and accompanying functional impairment. There has ... -
Targeted Sequencing of 10,198 Samples Confirms Abnormalities in Neuronal Activity and Implicates Voltage-Gated Sodium Channels in Schizophrenia Pathogenesis
Corvin, Aiden; Rees, Elliott; Carrera, Noa; Morgan, Joanne; Hambridge, Kirsty; Escott-Price, Valentina; Pocklington, Andrew J.; Richards, Alexander L.; Pardiñas, Antonio F.; McDonald, Colm; Donohoe, Gary; Morris, Derek W.; Kenny, Elaine; Kelleher, Eric; Gill, Michael; Kirov, George; Walters, James T.R.; Owen, Michael J.; O'Donovan, Michael C. (2019)Background Sequencing studies have pointed to the involvement in schizophrenia of rare coding variants in neuronally expressed genes, including activity-regulated cytoskeleton-associated protein (ARC) and N-methyl-D-aspartate ... -
Widespread white matter microstructural differences in schizophrenia across 4322 individuals: Results from the ENIGMA Schizophrenia DTI Working Group
Gill, Michael; Mc Carthy-Jones, Simon; Corvin, Aiden (2018)