Browsing by Author "FLEMING, ALASTAIR"
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Extracellular enzyme synthesis in a sporulation-deficient strain of Bacillus licheniformis.
FLEMING, ALASTAIR (American Society for Microbiology, 1995)A deletion of the spoIIAC gene of Bacillus licheniformis was prepared in vitro by using the splicing-by-overlapextension technique. This gene was introduced into B. licheniformis on a temperature-sensitive plasmid, and ... -
H2B ubiquitylation is part of chromatin architecture that marks exon-intron structure in budding yeast
FLEMING, ALASTAIR (2011)Background The packaging of DNA into chromatin regulates transcription from initiation through 3' end processing. One aspect of transcription in which chromatin plays a poorly understood role is the co-transcriptional ... -
Telomeric ORFs (TLOs) in Candida spp. Encode mediator subunits that regulate distinct virulence traits.
HARAN, JOHN; FLEMING, ALASTAIR; HOKAMP, KARSTEN (2014)The TLO genes are a family of telomere-associated ORFs in the fungal pathogens Candida albicans and C. dubliniensis that encode a subunit of the Mediator complex with homology to Med2. The more virulent pathogen C. ... -
Tup1-Ssn6 and Swi-Snf remodelling activities influence long-range chromatin organization upstream of the yeast SUC2 gene.
FLEMING, ALASTAIR (Oxford University Press, 2007)The traditional model for chromatin remodelling during transcription has focused upon the remodelling of nucleosomes at gene promoters. However, in this study, we have determined that Tup1-Ssn6 and Swi-Snf chromatin ...