Browsing by Author "FREELEY, MICHAEL"
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Advances in siRNA delivery to T-cells: potential clinical applications for inflammatory disease, cancer and infection.
FREELEY, MICHAEL; LONG, AIDEEN (2013)The specificity of RNAi and its ability to silence 'undruggable' targets has made inhibition of gene expression in T-cells with siRNAs an attractive potential therapeutic strategy for the treatment of inflammatory disease, ... -
Analysis of dynamic tyrosine phosphoproteome in LFA-1 triggered migrating T-cells.
LONG, AIDEEN; KELLEHER, DERMOT; DEMPSEY, EUGENE; VOLKOV, YURI; FREELEY, MICHAEL; VERMA, NAVIN (2011)The ordered, directional migration of T-lymphocytes is a key process during immune surveillance and response. This requires cell adhesion to the high endothelial venules or to the extracellular matrix by a series of surface ... -
Phosphorylation of Rab5a Protein by Protein Kinase Cϵ Is Crucial for T-cell Migration.
FREELEY, MICHAEL (2014)Rab GTPases control membrane traffic and receptor-mediated endocytosis. Within this context, Rab5a plays an important role in the spatial regulation of intracellular transport and signal transduction processes. Here, we ... -
Protein kinase C delta is a substrate of tissue transglutaminase and a novel autoantigen in coeliac disease
FREELEY, MICHAEL (2013)Post-translational modification of proteins by deamidation or transamidation by tissue transglutaminase (tTG) has been suggested as a possible mechanism for the development of autoimmunity. Sequence analysis of protein ... -
The Two Hit Hypothesis: An Improved Method for siRNA-Mediated Gene Silencing in Stimulated Primary Human T Cells.
FREELEY, MICHAEL (2013)Small interfering RNAs (siRNAs) have revolutionised cellular and molecular biology by uncovering new roles for genes in various biological processes and by providing new opportunities to silence gene expression for therapeutic ...