Browsing by Author "Ffrench, Brendan"
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Catching moving targets: Cancer stem cell hierarchies, therapy-resistance & considerations for clinical intervention
O'LEARY, JOHN; Gasch, Claudia; Ffrench, Brendan; O'Leary, John J.; Gallagher, Michael F. (2017)It is widely believed that targeting the tumour-initiating cancer stem cell (CSC) component of malignancy has great therapeutic potential, particularly in therapy-resistant disease. However, despite concerted efforts, ... -
Identification, isolation and validation of ovarian cancer stem cells
Ffrench, Brendan (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2013)Ovarian cancer is often diagnosed at a late stage. Even so, it often responds (~73 %) to first-line therapies. However, the five year survival rate for late stage ovarian cancer is poor (~27 %). It is hypothesised that ... -
MicroRNA-17 is downregulated in esophageal adenocarcinoma cancer stem-like cells and promotes a radioresistant phenotype
Maher, Stephen; Lynam-Lennon, Niamh; Reynolds, John; O'Leary, John; Heavey, Susan; Sommerville, Gary; Bibby, Becky A.S.; Ffrench, Brendan; Quinn, Jennifer; Gasch, Claudia; Gallagher, Michael F. (2017)Resistance to neoadjuvant chemoradiation therapy (CRT) remains a critical barrier to the effective treatment of esophageal adenocarcinoma (EAC). Cancer stem-like cells (CSCs) are a distinct subpopulation of cells implicated ...