Browsing by Author "Finn, Stephen"
Now showing items 1-6 of 6
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Development and characterisation of a panel of phosphatidylinositide 3-kinase - mammalian target of rapamycin inhibitor resistant lung cancer cell lines.
Barr, Martin; O'Byrne, Ken; Finn, Stephen; Gately, Kathy; Maher, Stephen (2018) -
Development of EphA2 siRNA-loaded lipid nanoparticles and combination with a small-molecule histone demethylase inhibitor in prostate cancer cells and tumor spheroids.
Gray, Steven; Oner-Bozkurt, Ezgi; Finn, Stephen; Baird, Anne-Marie (2021)Background siRNAs hold a great potential for cancer therapy, however, poor stability in body fluids and low cellular uptake limit their use in the clinic. To enhance the bioavailability of siRNAs in tumors, novel, safe, ... -
Genome wide investigation of papillary thyroid carcinoma
Finn, Stephen (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Histopathology & Morbid Anatomy, 2005)In recent years, there has been a technological explosion in the fields of molecular pathology and molecular oncology. The genome, transcriptome and increasingly the proteome of diverse tumours can now be analysed in minute ... -
In pursuit of synergy: An investigation of the PI3K/mTOR/MEK co-targeted inhibition strategy in NSCLC
O'Byrne, Ken; Finn, Stephen; Gately, Kathy (2016)Clinical PI3K inhibition has been somewhat disappointing, due to both inadequate patient stratification and compensatory cell signalling through bypass mechanisms. As such, investigation of PI3K-MEK co-targeted inhibition ... -
Pre-Treatment of Platinum Resistant Ovarian Cancer Cells with an MMP-9/MMP-2 Inhibitor Prior to Cisplatin Enhances Cytotoxicity as Determined by High Content Screening.
Norris, Lucy; Martin, Cara; O'Leary, John; Finn, Stephen; O'Toole, Sharon; Sheils, Orla; Abu Saadeh, Feras; Flavin, Richard; Kelly, Lynne (2013)Platinum resistance is a major cause of treatment failure in ovarian cancer. We previously identified matrix metalloproteinase 9 (MMP-9) as a potential therapeutic target of chemoresistant disease. A2780cis (cisplatin-resistant) ... -
SPINK1 protein expression and prostate cancer progression.
Finn, Stephen; Flavin, Richard (2014)PURPOSE: SPINK1 overexpression has been described in prostate cancer and is linked with poor prognosis in many cancers. The objective of this study was to characterize the association between SPINK1 overexpression and ...