Browsing by Author "Freeley, Michael"

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    • CD3ε Expression Defines Functionally Distinct Subsets of Vδ1 T Cells in Patients With Human Immunodeficiency Virus Infection. 

      Rogers, Thomas; Long, Aideen; Dunne, Margaret; Dunne, Pádraic J.; Maher, Christina O.; Freeley, Michael; Dunne, Katie; Petrasca, Andreea; Orikiiriza, Judy; Reidy, Derval; O'Dea, Siobhan; Loy, Aisling; Woo, Jim; Mulcahy, Fiona; Doherty, Derek G. (2018)
      Human γδ T cells expressing the Vδ1 T cell receptor (TCR) recognize self and microbial antigens and stress-inducible molecules in a major histocompatibility complex-unrestricted manner and are an important source of innate ...

    • Hepatitis C virus targets the T cell secretory machinery as a mechanism of immune evasion. 

      Long, Aideen; Petrovic, Danijela; Stamataki, Zania; Dempsey, Eugene; Golden-Mason, Lucy; Freeley, Michael; Doherty, Derek; Prichard, David; Keogh, Catherine; Conroy, Jennifer; Mitchell, Siobhan; Volkov, Yuri; McKeating, Jane A.; O'Farrelly, Cliona; Kelleher, Dermot (2011)
      T cell activation and the resultant production of interleukin (IL-2) is a central response of the adaptive immune system to pathogens, such as hepatitis C virus (HCV). HCV uses sev- eral mechanisms to evade both the ...

    • Phosphorylation of Rab5a protein by protein kinase Cϵ Is crucial for T-cell migration 

      Long, Aideen; Ong, Seow Theng; Freeley, Michael; Skubis-Zegladło, Joanna; Hussain Urf Turabe Fazil, Mobashar; Kelleher, Dermot; Fresser, Friedrich; Baier, Gottfried; Verma, Navin K. (2014)
      Rab GTPases control membrane traffic and receptor-mediated endocytosis. Within this context, Rab5a plays an important role in the spatial regulation of intracellular transport and signal transduction processes. Here, we ...

    • Regulating the Regulator: Phosphorylation of PKC θ in T Cells. 

      Long, Aideen; Freeley, Michael (2012)
      Protein kinase C θ (PKC θ) is a serine/threonine kinase that is now firmly established as a central component in T cell activation, proliferation, differentiation, and apoptosis (Hayashi and Altman, 2007). Since it was ...