Browsing by Author "HAMS, EMILY"
Now showing items 1-13 of 13
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Blockade of B7-H1 (Programmed Death Ligand 1) Enhances Humoral Immunity by Positively Regulating the Generation of T Follicular Helper Cells
FALLON, PADRAIC; HAMS, EMILY; AMU, SYLVIE (2011)T follicular helper (TFH) cells are critical initiators in the development of T cell-dependent humoral immunity and the generation of protective immunity. We demonstrate that TFH cell accumulation and Ab production are ... -
Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice.
FALLON, PADRAIC; HAMS, EMILY (2013)The cellular composition of visceral adipose tissue (VAT) and release of cytokines by such cells within VAT has been implicated in regulating obesity and metabolic homeostasis. We show the importance of IL-25-responsive ... -
Flotillin microdomains interact with the cortical cytoskeleton to control uropod formation and neutrophil recruitment
FALLON, PADRAIC; HAMS, EMILY (2010)We studied the function of plasma membrane microdomains defined by the proteins flotillin 1 and flotillin 2 in uropod formation and neutrophil chemotaxis. Flotillins become concentrated in the uropod of neutrophils after ... -
Helminth Modulation of Lung Inflammation
FALLON, PADRAIC; HAMS, EMILY (2018) -
The hydroxylase inhibitor DMOG attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B-1 cells.
FALLON, PADRAIC; HAMS, EMILY; SAUNDERS, SEAN (2011)Localized tissue hypoxia is a feature of infection and inflammation, resulting in the upregulation of the transcription factors HIF-1? and NF-?B via inhibition of oxygen sensing hydroxylase enzymes. Previous studies have ... -
Impaired basophil induction leads to an age-dependent innate defect in type 2 immunity during helminth infection in mice.
FALLON, PADRAIC; NEL, HENDRIK; HAMS, EMILY; SAUNDERS, SEAN (2011)Parasitic-infection studies on rhesus macaque monkeys have shown juvenile animals to be more susceptible to infection than adults, but the immunological mechanism for this is not known. In this study, we investigated the ... -
Ligation of TLR7 on CD19(+) CD1d(hi) B cells suppresses allergic lung inflammation via regulatory T cells.
FALLON, PADRAIC; SHEILS, ORLA; HAMS, EMILY (2015)B cells have been described as having the capacity to regulate cellular immune responses and suppress inflammatory processes. One such regulatory B-cell population is defined as IL-10-producing CD19(+) CD1d(hi) cells. ... -
Macrophage and Innate Lymphoid Cell Interplay in the Genesis of Fibrosis.
FALLON, PADRAIC; HAMS, EMILY (2015) -
MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4(+) T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion.
FALLON, PADRAIC; HAMS, EMILY (2014)Group 2 innate lymphoid cells (ILC2s) release interleukin-13 (IL-13) during protective immunity to helminth infection and detrimentally during allergy and asthma. Using two mouse models to deplete ILC2s in vivo, we demonstrate ... -
PD-L1(hi) B cells are critical regulators of humoral immunity.
FALLON, PADRAIC; HAMS, EMILY (2015) -
The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages.
FALLON, PADRAIC; HAMS, EMILY (2016) -
Perinatal Activation of the Interleukin-33 Pathway Promotes Type 2 Immunity in the Developing Lung.
FALLON, PADRAIC; HAMS, EMILY (2016) -
Regulation of IL-1?-induced NF-?B by hydroxylases links key hypoxic and inflammatory signaling pathways.
FALLON, PADRAIC; HAMS, EMILY (2013)Hypoxia is a prominent feature of chronically inflamed tissues. Oxygen-sensing hydroxylases control transcriptional adaptation to hypoxia through the regulation of hypoxia-inducible factor (HIF) and nuclear factor κB ...