Browsing by Author "Harkin, Andrew"
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Acute neuroinflammation, sickness behavior and working memory responses to acute systemic LPS challenge following noradrenergic lesion in mice
Cunningham, Colm; Harkin, Andrew (2021)Locus coeruleus (LC)-derived noradrenaline is important in cognition and decreases with age, but the impact of prior noradrenaline deficiency on vulnerability to inflammation-induced acute cognitive dysfunction is ... -
A role for adenosine A1 receptor blockade in the ability of caffeine to promote MDMA "Ecstasy"-induced striatal dopamine release
Harkin, Andrew (2011)Co-administration of caffeine profoundly enhances the acute toxicity of 3,4 methylenedioxymethamphetamine (MDMA) in rats. The aim of this study was to determine the ability of caffeine to impact upon MDMA-induced dopamine ... -
A role for serotonin in the antidepressant activity of NG Nitro-L-arginine in the rat forced swimming test
Harkin, Andrew (2009)The present study determined regional serotonin (5-HT) synthesis and metabolism changes associated with the nitric oxide synthase (NOS) inhibitor NG-nitro-L-arginine (L-NA) and the influence of 5-HT receptor blockade in ... -
Small-Molecule Inhibitors at the PSD-95/nNOS Interface have Antidepressant-Like Properties in Mice.
Harkin, Andrew; Dev, Kumlesh (2013)Previous studies have demonstrated that nitric oxide (NO) synthase inhibitors are as efficacious as tricyclic antidepressants in preclinical antidepressant screening procedures and in attenuating behavioural deficits ... -
Stress-Related Immune Markers in Depression: Implications for Treatment
Harkin, Andrew (2016)Major depression is a serious psychiatric disorder; however, the precise biological basis of depression still remains elusive. A large body of evidence implicates a dysregulated endocrine and inflammatory response system ... -
Stress-related regulation of the kynurenine pathway: Relevance to neuropsychiatric and degenerative disorders
Harkin, Andrew (2017)The kynurenine pathway (KP), which is activated in times of stress and infection has been implicated in the pathophysiology of neurodegenerative and psychiatric disorders. Activation of this tryptophan metabolising pathway ... -
Targeting the noradrenergic system for anti-inflammatory and neuroprotective effects: implications for Parkinson's disease.
Harkin, Andrew; O'Neill, Eoin (2018)Degeneration of the locus coeruleus noradrenergic system is thought to play a key role in the pathogenesis of Parkinson’s disease (PD), whereas pharmacological approaches to increase noradrenaline bioavailability may ...