Browsing by Author "Hudson, Natalie"
Now showing items 1-6 of 6
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Brain barriers virtual: an interim solution or future opportunity?
Hudson, Natalie (2022)Background: Scientific conferences are vital communication events for scientists in academia, industry, and government agencies. In the brain barriers research field, several international conferences exist that allow ... -
Differential apicobasal VEGF signaling at vascular blood-neural barriers
Campbell, Matthew; Hudson, Natalie (2014)The vascular endothelium operates in a highly polarized environment, but to date there has been little exploration of apicobasal polarization of its signaling. We show that VEGF-A, histamine, IGFBP3, and LPA trigger unequal ... -
Dysregulated claudin-5 cycling in the inner retina causes retinal pigment epithelial cell atrophy
Doyle, Sarah; Campbell, Matthew; Humphries, Peter; Hudson, Natalie (2019)Age-related macular degeneration (AMD) is the leading cause of central retinal vision loss worldwide, with an estimated 1 in 10 people over the age of 55 showing early signs of the condition. There are currently no forms ... -
Interleukin-33 regulates metabolic reprogramming of the retinal pigment epithelium in response to immune stressors
Lavelle, Edward; Campbell, Matthew; Hudson, Natalie (2021)It remains unresolved how retinal pigment epithelial cell metabolism is regulated following immune activation to maintain retinal homeostasis and retinal function. We exposed retinal pigment epithelium (RPE) to several ... -
Tight Junctions of the Neurovascular Unit
Campbell, Matthew; Hudson, Natalie (2021)The homeostatic balance of the brain and retina is maintained by the presence of the blood-brain and inner blood-retinal barrier (BBB/iBRB, respectively) which are highly specialized barriers. Endothelial cells forming the ... -
Tight junctions of the outer blood retina barrier
Campbell, Matthew; Hudson, Natalie (2020)The outer blood retina barrier (oBRB) formed by the retinal pigment epithelium (RPE) is critical for maintaining retinal homeostasis. Critical to this modified neuro-epithelial barrier is the presence of the tight junction ...