Browsing by Author "Johnston, Daniel"
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A role for microRNA-21 in the regulation of gastrointestinal health and disease
Johnston, Daniel (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2017)The gastrointestinal (GI) tract is a crucial site of innate and adaptive immune regulation, balancing tolerance of beneficial commensal microorganisms and reaction to invading pathgens. Pattern recognition receptors (PRRs), ... -
Differential role of Dok1 and Dok2 in TLR2-induced inflammatory signaling in glia.
Lynch, Marina; Downer, Eric; Johnston, Daniel (2013)Accumulating evidence continues to underpin the role of the innate immune system in pathologies associated with neuroinflammation. Innate immunity is regulated by pattern recognition receptors that detect pathogens, and ... -
Loss of microRNA-21 influences the gut microbiota causing reduced susceptibility in a murine model of colitis.
Corr, Sinead; O'Neill, Luke; Johnston, Daniel (2018)Background and aims: microRNAs regulate gene expression and influence the pathogenesis of human diseases. The present study investigated the role of microRNA-21 [miR-21] in the pathogenesis of intestinal inflammation, ... -
MicroRNA-21 Limits Uptake of Listeria monocytogenes by Macrophages to Reduce the Intracellular Niche and Control Infection.
Corr, Sinead; O'Neill, Luke; Johnston, Daniel (2017)MiRNAs are important post-transcriptional regulators of gene expression. MiRNA expression is a crucial part of host responses to bacterial infection, however there is limited knowledge of their impact on the outcome of ... -
Mycobacterium tuberculosis Limits Host Glycolysis and IL-1? by Restriction of PFK-M via MicroRNA-21
Sheedy, Frederick; Keane, Joseph; Corr, Sinead; Lavelle, Edward; Johnston, Daniel; Gleeson, Laura; Munoz-Wolf, Natalia (2020)Increased glycolytic metabolism recently emerged as an essential process driving host defense against Mycobacterium tuberculosis (Mtb), but little is known about how this process is regulated during infection. Here, we ... -
MyD88 adaptor-like (Mal) regulates intestinal homeostasis and colitis-associated colorectal cancer in mice.
Fallon, Padraic; Corr, Sinead; Johnston, Daniel (2014)Toll-like receptors (TLRs) play a central role in the recognition and response to microbial pathogens and in the maintenance and function of the epithelial barrier integrity in the gut. The protein MyD88 adaptor-like ... -
Pyruvate Kinase M2 Regulates Hif-1alfa Activity and IL-1? Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages.
Palsson Mcdermott, Eva; Keane, Joseph; O'Neill, Luke; Sheedy, Frederick; Johnston, Daniel; Gleeson, Laura (2015)TLR4-activated macrophages switch their metabolism from oxidative phosphorylation to glycolysis to rapidly provide for the high energy and biosynthetic demands of infection or injury response. Palsson-McDermott identify ...