Browsing by Author "KELLY, DANIEL JOHN"
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An Argument for the Use of Multiple Segment Stents in Curved Arteries
KELLY, DANIEL JOHN (2011)Stenting of curved arteries is generally perceived to be more challenging than straight vessels. Conceptually implanting multiple shorter stents rather than a single longer stent into such a curved artery represents a ... -
European Society of Biomechanics S.M. Perren Award 2012: The external mechanical environment can override the influence of local substrate in determining stem cell fate.
KELLY, DANIEL JOHN; THORPE, STEPHEN; STEWARD, ANDREW; BUCKLEY, CONOR TIMOTHY (2012)The aim of this study was to explore how cell-matrix interactions and extrinsic mechanical signals interact to determine stem cell fate in response to transforming growth factor-?3 (TGF-?3). Bone marrow derived mesenchymal ... -
Exploring the roles of integrin binding and cytoskeletal reorganization during mesenchymal stem cell mechanotransduction in soft and stiff hydrogels subjected to dynamic compression
KELLY, DANIEL JOHN (2013)The objective of this study was to explore how the response of mesenchymal stem cells (MSCs) to dynamic compression (DC) depends on their pericellular environment and the development of their cytoskeleton. MSCs were first ... -
The role of environmental factors in regulating the development of cartilaginous grafts engineered using osteoarthritic human infrapatellar fat pad-derived stem cells.
KELLY, DANIEL JOHN; BUCKLEY, CONOR TIMOTHY (2012)Engineering functional cartilaginous grafts using stem cells isolated from osteoarthritic human tissue is of fundamental importance if autologous tissue engineering strategies are to be used in the treatment of diseased ... -
The role of the superficial region in determining the dynamic properties of articular cartilage.
KELLY, DANIEL JOHN; GANNON, ALANNA (2012)OBJECTIVE: The objective of this study was to elucidate the role of the superficial region of articular cartilage in determining the dynamic properties of the tissue. It is hypothesised that removal of the superficial ... -
Site specific inelasticity of arterial tissue.
KELLY, DANIEL JOHN; LALLY, CAITRIONA (2012)Understanding the mechanical behaviour of arterial tissue is vital to the development and analysis of medical devices targeting diseased vessels. During angioplasty and stenting, stress softening and permanent deformation ... -
Substrate stiffness and oxygen as regulators of stem cell differentiation during skeletal tissue regeneration: a mechanobiological model.
KELLY, DANIEL JOHN (2012)Extrinsic mechanical signals have been implicated as key regulators of mesenchymal stem cell (MSC) differentiation. It has been possible to test different hypotheses for mechano-regulated MSC differentiation by attempting ...