Browsing by Author "KELLY, JOHN"
Now showing items 1-15 of 15
-
Controlled dehydration of a ruthenium complex-DNA crystal induces reversible DNA kinking
KELLY, JOHN (2014)Hydration-dependent DNA deformation has been known since Rosalind Franklin recognised that the relative humidity of the sample had to be maintained to observe a single conformation in DNA fibre diffraction. We now report ... -
Direct observation by time-resolved infrared spectroscopy of the bright and the dark excited states of the [Ru(phen)2(dppz)]2+ light-switch compound in solution and when bound to DNA
KELLY, JOHN; GUNNLAUGSSON, THORFINNUR (2016)The [Ru(phen)2(dppz)]2+ complex (1) is non-emissive in water but is highly luminescent in organic solvents or when bound to DNA, making it a useful probe for DNA binding. To date, a complete mechanistic explanation for ... -
The effect of the 4-amino functionality on the photophysical and DNA binding properties of alkyl-pyridinium derived 1,8-naphthalimides
GUNNLAUGSSON, THORFINNUR; KELLY, JOHN (2013)The synthesis and characterisation of two cationic pyridinium based 4-amino-1,8-naphthalimide derivatives (2 and 3) are described and compared to those of compound 1. The photophysical properties of 2 and 3 are shown to ... -
Excited state behaviour of substituted dipyridophenazine Cr(III) complexes in the presence of nucleic acids.
KELLY, JOHN (2010)The photophysics and photochemistry of [Cr(phen)2(dppz)]3+ and its 11,12-substituted derivatives [Cr(phen)2(X2dppz)]3+ {X = Me or F} have been studied in the presence of purine nucleotides or DNA using steady state and ... -
Long-lived excited states in i-motif DNA studied by picosecond time-resolved IR spectroscopy
KELLY, JOHN (2014)The transient IR absorption spectrum for UV-excited i-motif DNA is reported for the first time and found to possess complex dynamics pointing to multiple decay processes, including possible charge transfer between packed ... -
Microwave-assisted synthesis of ZnO micro-javelins
KELLY, JOHN (2009)The microwave (MW)-assisted formation of ZnO micro-javelins from zinc nitrate and urea in aqueous solution is described. The particles (named as `micro-javelins? because of their high aspect ratio and needle-like tips) ... -
Photophysical studies of CdTe quantum dots in the presence of a zinc cationic porphyrin
KELLY, JOHN; GOUNKO, IOURI (2012)The photophysical properties of 2.3 nm thioglycolic acid (TGA) coated CdTe quantum dots (QDs) prepared by a reflux method have been studied in the presence of cationic meso-tetrakis(4-Nmethylpyridyl) zinc porphyrin ... -
ps-TRIR Covers All the Bases - Recent Advances in the Use of Transient IR for the Detection of Ultrafast Species in DNA
KELLY, JOHN (2009)Recent developments of the picosecond transient absorption infrared technique and its ability to elucidate the nature and kinetic behaviour of transient species formed upon pulsed laser excitation of nucleic acids are described. -
Recent advances in the development of 1,8-naphthalimide based DNA targeting binders, anticancer and fluorescent cellular imaging agents.
KELLY, JOHN; BANERJEE, SWAGATA; GUNNLAUGSSON, THORFINNUR (2013)The development of functional 1,8-naphthalimide derivatives as DNA targeting, anticancer and cellular imaging agents is a fast growing area and has resulted in several such derivatives entering into clinical trials. This ... -
Substituted dipyridophenazine complexes of Cr(III): synthesis, enantiomeric resolution and binding interactions with calf thymus DNA.
KELLY, JOHN; MCCABE, THOMAS (2010)[Cr(phen)2(X2dppz)]3+ {X = H, Me, or F} have been synthesised, characterised, and chromatographically resolved into their constituent ? and ? enantiomers. The DNA-binding interactions of each of the racemic complexes were ... -
Synthesis and spectroscopic studies of chiral CdSequantum dots
GOUNKO, IOURI; KELLY, JOHN; GALLAGHER, SHANE (2010)Using microwave irradiation, water soluble, optically active, penicillamine (Pen) capped CdSenanocrystals with broad spectral distribution (430?780 nm) of photoluminescence have been produced and studied by a range of ... -
Transient Spectroscopy of Dipyridophenazine Metal Complexes which undergo electron transfer with DNA
KELLY, JOHN (2011)This review considers transient spectroscopic studies of electron transfer reactions between nucleic acids and the excited states of transition metal complexes containing dipyridophenazine or related ligands and focuses ... -
Ultrafast IR spectroscopy of polymeric cytosine nucleic acids reveal the long-lived species is due to a localised state
KELLY, JOHN (2012)The decay pathways of UV-excited cytosine polymers are investigated using picosecond time-resolved infrared spectroscopy. Similar yields of a non-emissive 1niU* state are found in the single-stranded dC30 polymer as in the ... -
Understanding the DNA binding of novel non-symmetrical guanidinium/2-aminoimidazolinium derivatives.
KHAN, AMIR; ROZAS, ISABEL; O'DONOVAN, DANIEL HILLEBRAND; NAGLE, PADRAIC; KELLY, JOHN (2010)Biophysical studies have been carried out on a family of asymmetric guanidinium-based diaromatic derivatives to assess their potential as DNA minor groove binding agents. To experimentally assess the binding of these ... -
Wash-free highly sensitive detection of C-reactive protein using gold derivatised triangular silver nanoplates
GOUNKO, IOURI; BLAU, WERNER; KELLY, JOHN (2014)A rapid, wash-free highly sensitive detection method for C-reactive protein (hs-CRP) is reported with both triangular silver nanoplate (TSNP) and Au-edge coated TSNP biosensor sols. The latter shows higher assay sensitivity ...