Browsing by Author "Kelly, Aine"
Now showing items 1-7 of 7
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Activation of p38 plays a pivotal role in the inhibitory effect of lipopolysaccharide and interleukin-1beta-induced inhibition of long-term potentiation in rat dentate gyrus
Lynch, Marina; Kelly, Aine; Mills, Kingston (2003)Lipopolysaccharide (LPS), a component of the cell wall of Gram-negative bacteria, has been shown to induce profound changes both peripherally and centrally. It has recently been reported that intraperitoneal injection of ... -
Aerobic exercise improves hippocampal function and increases BDNF in the serum of young adult males
Kelly, Aine; O'Mara, Shane (2011)Physical activity has been reported to improve cognitive function in humans and rodents, possibly via a brain-derived neurotrophic factor (BDNF)-regulated mechanism. In this study of human subjects, we have assessed the ... -
The age-related deficit in LTP is associated with changes in perfusion and blood-brain barrier permeability.
Kerskens, Christian; Lynch, Marina; Kelly, Aine (2012)In view of the increase in the aging population and the unavoidable parallel increase in the incidence of age-related neurodegenerative diseases, a key challenge in neuroscience is the identification of clinical signatures ... -
The anti-inflammatory cytokine, interleukin (IL)-10, blocks the inhibatory effect of IL-1 beta on long term potentiation - a role for JNK
Lynch, Marina; Lynch, Aileen; Kelly, Aine; O'Neill, Luke (2001)Several effects of the proinflammatory cytokine, interleukin-1? (IL-1?), have been described in the central nervous system, and one area of the brain where marked changes have been reported is the hippocampus. Among these ... -
BDNF-stimulated intracellular signalling mechanisms underlie exercise-induced improvement in spatial memory in the male Wistar rat.
Kelly, Aine (2014)Exercise-induced improvements in learning are associated with neurotrophic and neurogenic changes in the dentate gyrus, but the intracellular signalling mechanisms that may mediate these improvements remain unknown. In the ... -
Cardiovascular risk and systemic inflammation in male professional rugby: a cross-sectional study
Wilson, Fiona; Fearon, Ursula; Kelly, Aine (2023)Objective To investigate cardiovascular risk factors’ prevalence and association with systemic inflammation in professional male rugby players (RP). Methods A cross-sectional investigation of 46 professional male RP ... -
'Recovery' in the real world: service user experiences of mental health service use and recommendations for change 20 years on from a First Episode Psychosis
O'KEEFFE, DONAL PADRAIG; Sheridan, Ann; Kelly, Aine; Doyle, Roisin; Madigan, Kevin; Lawlor, Elizabeth; Clarke, Mary (2018)Little is known about how recovery oriented policy and legislative changes influence service users’ perceptions of mental health care over time. Although the recovery approach is endorsed in many countries, qualitative ...