Browsing by Author "Little, Mark"
Now showing items 1-19 of 19
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2020 international consensus on ANCA testing beyond systemic vasculitis
Little, Mark (2020)This document follows up on a 2017 revised international consensus on anti-neutrophil cytoplasm antibodies (ANCA) testing in granulomatosis with polyangiitis and microscopic polyangiitis and focuses on the clinical and ... -
Alkylating histone deacetylase inhibitors may have therapeutic value in experimental myeloperoxidase-ANCA vasculitis
Brady, Gareth; Little, Mark (2018)Current therapies for treating antineutrophil cytoplasm autoantibody (ANCA)–associated vasculitis include cyclophosphamide and corticosteroids. Unfortunately, these agents are associated with severe adverse effects, despite ... -
Autosomal dominant tubulointerstitial kidney disease (ADTKD) in Ireland.
Little, Mark; Cormican, S.; Connaughton, D.M.; Kennedy, C.; Murray, S.; Živná, M.; Kmoch, S.; Fennelly, N.K.; O'Kelly, P.; Benson, K.A.; Conlon, E.T.; Cavalleri, G.; Foley, C.; Doyle, B.; Dorman, A.; Lavin, P.; Kidd, K.; Bleyer, A.J.; Conlon, P.J. (2019)Introduction: Autosomal dominant tubulointerstitial kidney disease (ADTKD) is a rare genetic cause of renal impairment resulting from mutations in the MUC1, UMOD, HNF1B, REN, and SEC61A1 genes. Neither the national or ... -
Comparisons of Guidelines and Recommendations on Managing Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
Little, Mark; Geetha, Duvuru; Jin, Quiyu; Scott, Jennifer; Hruskova, Zdenka; Hanouneh, Mohamad; Tesar, Vladimir; Seo, Philip; Jayne, David; Pagnoux, Christian (2018)Antineutrophil cytoplasmic antibodies−associated vasculitis (AAV) is associated with high morbidity or mortality, especially if not promptly diagnosed and treated. Many inroads have been made in the understanding of the ... -
The complications of vasculitis and its treatment
Little, Mark; King, Catherine; Harper, Lorraine (2018)Survival following a diagnosis of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) has improved since the introduction of cyclophosphamide-based immunosuppressive regimens and is now almost 80% at 5 ... -
Data linkage in medical science using the resource description framework: the AVERT model
O'Sullivan, Declan; Little, Mark; Hederman, Lucy (2018)There is an ongoing challenge as to how best manage and understand ‘big data’ in precision medicine settings. This paper describes the potential for a Linked Data approach, using a Resource Description Framework (RDF) ... -
Efficacy and Safety of Belimumab and Azathioprine for Maintenance of Remission in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Randomized Controlled Study
Little, Mark; Jayne, David; Blockmans, Daniel; Luqmani, Raashid; Moiseev, Sergey; Ji, Beulah; Green, Yulia; Hall, Leanne; Roth, David; Henderson, Robert B.; Merkel, Peter A. (2019)Objective: To evaluate the safety and efficacy of belimumab as adjunctive therapy to maintain remission in antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV). Methods: In this multicenter, ... -
Environmental risk factors associated with ANCA associated vasculitis: A systematic mapping review.
Little, Mark; Mockler, David (2020)Background: Anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) is a rare multi-system autoimmune disease, characterised by a pauci-immune necrotising small-vessel vasculitis, with a relapsing and remitting ... -
Evaluating the usability of a semantic environmental health data framework: approach and study
Navarro Gallinad, Albert; O'Sullivan, Declan; Orlandi, Fabrizio; Little, Mark (2023)Environmental exposures transported across air, land and water can affect our health making us more susceptible to developing a disease. Therefore, researchers need to face the complex task of integrating environmental ... -
Examining the utility of cystatin C as a confirmatory test of chronic kidney disease across the age range in middle-aged and older community-dwelling adults
Little, Mark; Kenny, Rose; Canney, Mark; Sexton, Donal J.; O'Leary, Neil; Healy, Martin; O'Seaghdha, Conall M. (2018)Background: Cystatin C has been proposed as a confirmatory test of chronic kidney disease (CKD). This is most applicable to older individuals with CKD, the majority of whom have a creatinine-based estimated glomerular ... -
Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status
Little, Mark; Conlon, Niall (2019)Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare inflammatory disease of unknown cause. 30% of patients have anti-neutrophil cytoplasmic antibodies (ANCA) specific for myeloperoxidase (MPO). Here, we describe ... -
Intermediate monocytes in ANCA vasculitis: increased surface expression of ANCA autoantigens and IL-1? secretion in response to anti-MPO antibodies.
Little, Mark; Hickey, Fionnuala; O'Brien, Eoin (2015) -
Low Density Granulocytes in ANCA Vasculitis Are Heterogenous and Hypo-Responsive to Anti-Myeloperoxidase Antibodies
Doyle, Sarah; Little, Mark; Fearon, Ursula; Moran, Barry (2019)Low Density Granulocytes (LDGs), which appear in the peripheral blood mononuclear cell layer of density-separated blood, are seen in cancer, sepsis, autoimmunity, and pregnancy. Their significance in ANCA vasculitis (AAV) ... -
Neutrophils: Need for Standardized Nomenclature
Little, Mark; Kelly, Lynne; Stevenson, Nigel (2021)Neutrophils are the most abundant innate immune cell with critical anti-microbial functions. Since the discovery of granulocytes at the end of the nineteenth century, the cells have been given many names including phagocytes, ... -
Pro-inflammatory Stimulation of Monocytes by ANCA Is Linked to Changes in Cellular Metabolism
Little, Mark (2020)Clinical and experimental data suggest that pathogenesis in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is driven by ANCA-mediated activation of neutrophils and monocytes. While the role of neutrophils ... -
The relationship between kidney function and quality of life among community-dwelling adults varies by age and filtration marker
Little, Mark; Kenny, Rose; Tobin, Katy (2018)Background: The impact of a diminished level of kidney function on the well-being of an older individual is poorly understood. We sought to determine the association between estimated glomerular filtration rate (eGFR) and ... -
Sphingosine-1-phosphate receptor modulator FTY720 attenuates experimental myeloperoxidase-ANCA vasculitis in a T cell-dependent manner
Little, Mark (2020)Sphingosine-1-phosphate (S1P) is a pleiotropic lysosphingolipid derived from the metabolism of plasma membrane lipids. The interaction between S1P and its ubiquitously expressed G-protein-coupled receptors (S1PR1-5) is ... -
Study Protocol for DeCOmPRESS: Defining the Disease Course and Immune Profile of COVID-19 in the Immunosuppressed Patient
Brady, Gareth; Little, Mark; O'Sullivan, Declan (2021)The ongoing coronavirus disease 2019 (COVID-19) pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Current advisory guidelines for high-risk groups—including people with autoimmune disease ... -
Towards A Rare Disease Registry Standard: Semantic Mapping of Common Data Elements Between FAIRVASC and the European Joint Programme for Rare Disease
Yaman, Beyza; Hederman, Lucy; O'Sullivan, Declan; Little, Mark; McGlinn, Kris (2022)This paper describes the extension of the FAIRVASC rare disease ontology, with Joint Research Council Common Data Elements (CDE), and mapping to the European Joint Programme on Rare Dis- eases (EJP RD) CDE ontology. We ...