Browsing by Author "MERIKANGAS, ALISON"
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Convergence of Genes and Cellular Pathways Dysregulated in Autism Spectrum Disorders
MERIKANGAS, ALISON; GALLAGHER, LOUISE; BOLSHAKOVA, NADIA (2014)Rare copy-number variation (CNV) is an important source of risk for autism spectrum disorders (ASDs). We analyzed 2,446 ASD-affected families and confirmed an excess of genic deletions and duplications in affected versus ... -
A genomewide scan for common alleles affecting risk for autism.
ANNEY, RICHARD; GALLAGHER, LOUISE; GILL, MICHAEL; BOLSHAKOVA, NADIA; SEGURADO, RICARDO; HERON, ELIZABETH; MCGRATH, JANE; TANSEY, KATHERINE; BRENNAN, SEAN; MERIKANGAS, ALISON; MERIKANGAS, ALISON KATHLEEN (2010)Although autism spectrum disorders (ASDs) have a substantial genetic basis, most of the known genetic risk has been traced to rare variants, principally copy number variants (CNVs). To identify common risk variation, the ... -
Individual common variants exert weak effects on the risk for autism spectrum disorderspi.
ANNEY, RICHARD; MERIKANGAS, ALISON; HERON, ELIZABETH; GILL, MICHAEL; GALLAGHER, LOUISE (2012)While it is apparent that rare variation can play an important role in the genetic architecture of autism spectrum disorders (ASDs), the contribution of common variation to the risk of developing ASD is less clear. To ... -
A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder.
ANNEY, RICHARD; MERIKANGAS, ALISON; MCGRATH, JANE; GALLAGHER, LOUISE (2012)Autism spectrum disorder (ASD) is a highly heritable disorder of complex and heterogeneous aetiology. It is primarily characterized by altered cognitive ability including impaired language and communication skills and ...