Browsing by Author "MILLS, KINGSTON"
Now showing items 1-20 of 89
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Activation of mixed glia by A-beta-specific Th1 and Th17 cells and its regulation by Th2 cells
MILLS, KINGSTON; MCQUILLAN, KEITH; LYNCH, MARINA (2010)Microglia are innate immune cells of the CNS, that act as antigen-presenting cells (APC) for antigen-specific T cells and respond to inflammatory stimuli, such as amyloid-beta (A?), resulting in the release of neurotoxic ... -
Adenosine A(2A) receptors control neuroinflammation and consequent hippocampal neuronal dysfunction.
LYNCH, MARINA; MILLS, KINGSTON (2011)The blockade of adenosine A2A receptors (A2AR) affords a robust neuroprotection in different noxious brain conditions. However, the mechanisms underlying this general neuroprotection are unknown. One possible mechanism ... -
Adenylate cycalse toxin of Bordetella pertussis inhibits TLR-induced IRF-1 and IRF-8 activation and IL-12 production and enhances IL-10 through MAPK activation in dendritic cells
MILLS, KINGSTON (Society of Leukocyte Biology, 2008)Adenylate cyclase toxin (CyaA) of Bordetella pertussis binds to CD11b/CD18 on macrophages and dendritic cells (DC) and confers virulence to the bacteria by subverting innate immune responses of the host. We have previously ... -
Adenylate cyclase toxin from Bordetella pertussis synergises with lipopolysaccharide to promote innate IL-10 production and enhance the induction of Th2 and regulatory T cells
LAVELLE, EDWARD; MILLS, KINGSTON (American Society for Microbiology, 2004)Adenylate cyclase toxin (CyaA) from Bordetella pertussis can subvert host immune responses allowing bacterial colonization. Here we have examined its adjuvant and immunomodulatory properties and the possible contribution ... -
Altered Expression of Caspases-4 and -5 during Inflammatory Bowel Disease and Colorectal Cancer - Novel Diagnostic and Therapeutic Potential.
MILLS, KINGSTON; CREAGH, EMMA (2015)Caspases are a group of proteolytic enzymes involved in the co-ordination of cellular processes, including cellular homeostasis, inflammation and apoptosis. Altered activity of caspases, particularly caspase-1, has ... -
Alveolar Macrophages Contribute to Respiratory Tolerance by Inducing FoxP3 Expression in Naive T Cells
MILLS, KINGSTON; KEANE, JOSEPH; RUANE, DARREN; COLEMAN, MICHELLE; MORAN, BARRY (2013)Alveolar macrophages (AMs) from mice and humans have long been known to contribute to maintaining tolerance in the lung. Studies have shown that AMs can induce anergy in CD4+ T cells. Nitric oxide, prostaglandins, and ... -
The Appearance of escape variants in vivo does not account for the failure of recombinant envelope vaccines to protect against simian immunodeficiency virus
MILLS, KINGSTON (Society for General Microbiology, 1999)The presence or evolution of immune escape variants has been proposed to account for the failure of recombinant envelope vaccines to protect macaques against challenge with simian immunodeficiency virus (SIVmac). To address ... -
Attenuating regulatory T cell induction by TLR agonists through inhibition of p38 MAPK signaling in dendritic cells enhances their efficacy as vaccine adjuvants and cancer immunotherapeutics
CONROY, HELEN; FLETCHER, JEAN; LAVELLE, EDWARD; MILLS, KINGSTON (The American Association of Immunologists, 2008)TLR ligands are potent adjuvants and promote Th1 responses to coadministered Ags by inducing innate IL-12 production. We found that TLR ligands also promote the induction of IL-10-secreting regulatory T (Treg) cells through ... -
Atypical disease after Bordetella pertussis respiratory infection of mice with targeted disruptions in IFN- ? receptor or immunoglobulin Y chain genes
MILLS, KINGSTON (The Rockefeller University Press, 1997)Using a murine respiratory challenge model we have previously demonstrated a role for Th1 cells in natural immunity against Bordetella pertussis, but could not rule out a role for antibody. Here we have demonstrated that ... -
Atypical disease after Bordetella pertussis respiratory infection of mice with targeted disruptions in Interferon- Receptor or Immunoglobulin ? Chain Genes
MILLS, KINGSTON (The Rockefeller University Press, 1997)Using a murine respiratory challenge model we have previously demonstrated a role for Th1 cells in natural immunity against Bordetella pertussis, but could not rule out a role for antibody. Here we have demonstrated that ... -
Autophagy and inflammatory diseases.
MILLS, KINGSTON (2013)Autophagy is a cellular mechanism for the sequestration and degradation of intracellular pathogens and compromised organelles, particularly damaged mitochondria. Autophagy also clears other cellular components, such as ... -
Blocking retinoic acid receptor-α enhances the efficacy of a dendritic cell vaccine against tumours by suppressing the induction of regulatory T cells
GALVIN, KAREN; HIGGINS, SARAH; MILLS, KINGSTON; STEFANSKA, ANNA; MORAN, BARRY; DUNGAN, LARA (2013)The immune system has evolved regulatory mechanisms to control immune responses to self-antigens. Regulatory T (Treg) cells play a pivotal role in maintaining immune tolerance, but tumour growth is associated with local ... -
Booster immunization of children with an acellular pertussis vaccine enhances Th2 cytokine production and serum IgE against pertussis toxin but not against common allergens
MILLS, KINGSTON (British Society for Immunology, 2000)Acellular pertussis vaccines (Pa) protect against severe pertussis in children. However, serum antibody responses decline quickly after immunization. Studies in animal models suggest that cell-mediated immunity also ... -
Bordetella adenylate cyclase toxin differentially modulates toll-like receptor-stimulated activation, migration and T cell stimulatory capacity of dendritic cells.
MILLS, KINGSTON (2014)Adenylate cyclase toxin (CyaA) is a key virulence factor of the whooping cough agent Bordetella pertussis. The toxin targets CD11b-expressing phagocytes and delivers into their cytosol an adenylyl cyclase (AC) enzyme that ... -
Bordetella pertussis adenylate cyclase toxin modulates innate and adaptive immune responses: distinct roles for acylation and enzymatic activity in immunomodulation and cell death
LAVELLE, EDWARD; MILLS, KINGSTON (The American Association of Immunologists, 2005)Adenylate cyclase toxin (CyaA) of Bordetella pertussis belongs to the repeat in toxin family of pore-forming toxins, which require posttranslational acylation to lyse eukaryotic cells. CyaA modulates dendritic cell (DC) ... -
Bordetella pertussis expresses a functional type III secretion system that subverts protective innate and adaptive immune responses.
MILLS, KINGSTON; ROSS, PADRAIG JOHN (American Society for Microbiology, 2008)Certain bacteria use a type III secretion system (TTSS) to deliver effector proteins that interfere with cell function into host cells. While transcription of genes encoding TTSS components has been demonstrated, studies ... -
CD11c+CD8alpha+ dendritic cells promote protective immunity to respiratory infection with Bordetella pertussis.
MILLS, KINGSTON; MORAN, BARRY (The American Association of Immunologists, 2009)CD11c+CD8?+ and CD103+ DC have been shown to promote regulatory T cell responses and mediate tolerance in the gastrointestinal tract. These cells have also been identified in the lung, but their role in immunity to ... -
CD200 ligand receptor interaction modulates microglial activation in vivo and in vitro: a role for IL-4.
LYNCH, MARINA ANNETTA; MILLS, KINGSTON (Society for Neuroscience, 2007)Deficits in cognitive function are associated with neuroinflammatory changes, typified by activation of glial cells and an alteration of the pro- and anti-inflammatory cytokine balance in the brain. Although there is ... -
Cell mediated immunity to Bordetella pertussis: role of Th1 cells in bacterial clearance in a murine respiratory infection model
MILLS, KINGSTON (American Society for Microbiology, 1993)A murine respiratory infection model was used to study the mechanism of protective immunity to Bordetella pertussis. We found that nude mice, which are deficient in T cells, developed a persistent infection and failed to ...