Browsing by Author "MINOGUE, AEDIN"
Now showing items 1-7 of 7
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Age-associated dysregulation of microglial activation is coupled with enhanced BBB permeability and pathology in APP/PS1 mice
LYNCH, MARINA; MINOGUE, AEDIN (2014)Aging adversely affects inflammatory processes in the brain, which has important implications in the context of disease progression. It has been proposed that microglia become dysfunctional with age and may lose their ... -
Amyloid-beta-Induced Astrocytic Phagocytosis is Mediated by CD36, CD47 and RAGE.
LYNCH, MARINA ANNETTA; MINOGUE, AEDIN (2013) -
Bone Marrow-Derived Macrophages from AβPP/PS1 Mice are Sensitized to the Effects of Inflammatory Stimuli.
LYNCH, MARINA; MINOGUE, AEDIN; MINOGUE, AEDIN; LYNCH, MARINA ANNETTA (2015)Macrophages are key cells in tissue defense in the periphery and, under certain circumstances, infiltrate the central nervous system, where they may play a similar role in the brain, perhaps supporting the function of ... -
Glial Activation in A?PP/PS1 Mice is Associated with Infiltration of IFN?-Producing Cells.
LYNCH, MARINA ANNETTA; COSTELLO, DEREK; MINOGUE, AEDIN (2013) -
Impaired performance of female APP/PS1 mice in the Morris water maze is coupled with increased A? accumulation and microglial activation.
LYNCH, MARINA ANNETTA; MINOGUE, AEDIN (2013)Background: Alzheimer?s Disease is characterized by progressive neuronal loss and cognitive decline. Epidemiological studies suggest that the risk of AD is higher in women even when data are adjusted for age. Objective: ... -
Inhibition of JAK2 attenuates the increase in inflammatory markers in microglia from APP/PS1 mice
LYNCH, MARINA; MINOGUE, AEDIN (2015)There is a wealth of evidence indicating that macrophages adopt distinct phenotypes when exposed to specific stimuli and, in the past few years, accumulating data suggest that microglia behave somewhat similarly. Therefore, ... -
LPS-induced release of IL-6 from glia modulates production of IL-1? in a JAK2-dependent manner.
MINOGUE, AEDIN; BARRETT, JAMES; LYNCH, MARINA ANNETTA (2012)Background: Compelling evidence has implicated neuroinflammation in the pathogenesis of a number of neurodegenerative conditions. Chronic activation of both astrocytes and microglia leads to excessive secretion ...