Browsing by Author "Mcgouran, Joanna"
Now showing items 1-4 of 4
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A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A
Mcgouran, Joanna; Senge, Mathias; Scanlan, Eoin (2019)Nine modified nucleosides, incorporating zinc-binding pharmacophores, have been synthesised and evaluated as inhibitors of the DNA repair nuclease SNM1A. The series included oxyamides, hydroxamic acids, hydroxamates, a ... -
Molecular basis of USP7 inhibition by selective small-molecule inhibitors.
Mcgouran, Joanna (2017)Ubiquitination controls the stability of most cellular proteins, and its deregulation contributes to human diseases including cancer. Deubiquitinases remove ubiquitin from proteins, and their inhibition can induce the ... -
Optimised oligonucleotide substrates to assay XPF-ERCC1 nuclease activity for the discovery of DNA repair inhibitors
Mcgouran, Joanna (2019)We report the design and optimisation of novel oligonucleotide substrates for a sensitive fluorescence assay for high-throughput screening and functional studies of the DNA repair enzyme, XPFERCC1, with a view to ... -
Strategies to Target Specific Components of the Ubiquitin Conjugation/Deconjugation Machinery
Mcgouran, Joanna (2020)The regulation of ubiquitination status in the cell is controlled by ubiquitin ligases acting in tandem with deubiquitinating enzymes. Ubiquitination controls many key processes in the cell from division to death making ...