Browsing by Author "Moran, Barry"
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Differential regulation of human Treg and Th17 cells by fatty acid synthesis and glycolysis
Phelan, Andreea; Fletcher, Jean; Moran, Barry (2019)In this study we examined the metabolic requirements of human T helper cells and the effect of manipulating metabolic pathways in Th17 and Treg cells. The Th17:Treg cell axis is dysregulated in a number of autoimmune or ... -
Digital radiography exposure indices: A review.
Moran, Barry (2014)Digital radiography (DR) technologies have the advantage of a wide dynamic range compared to their film-screen predecessors, however, this poses a potential for increased patient exposure if left unchecked. Manufacturers ... -
Enriched CD141+ DCs in the joint are transcriptionally distinct, activated, and contribute to joint pathogenesis.
Fletcher, Jean; Fearon, Ursula; Moran, Barry; Canavan, Mary (2018)CD141+ DC are implicated in antiviral and antitumor immunity. However, mechanisticstudies in autoimmune disease are limited. This is the first study to our knowledgeexamining CD141+ DC in autoimmune disease, specifically ... -
Extracellular vesicles report on the MET status of their cells of origin regardless of the method used for their isolation.
Moran, Barry; O'Driscoll, Lorraine (2020)MET pathway is an important actionable target across many solid tumour types and several MET inhibitors have been developed. Extracellular vesicles (EVs) are proposed to be mini-maps of their cells of origin. However, the ... -
IL-17 mediates protective immunity against nasal infection with Bordetella pertussis by mobilizing neutrophils, especially Siglec-F + neutrophils
Moran, Barry; Mills, Kingston (2021)Understanding the mechanism of protective immunity in the nasal mucosae is central to the design of more effective vaccines that prevent nasal infection and transmission of Bordetella pertussis. We found significant ... -
Low Density Granulocytes in ANCA Vasculitis Are Heterogenous and Hypo-Responsive to Anti-Myeloperoxidase Antibodies
Doyle, Sarah; Little, Mark; Fearon, Ursula; Moran, Barry (2019)Low Density Granulocytes (LDGs), which appear in the peripheral blood mononuclear cell layer of density-separated blood, are seen in cancer, sepsis, autoimmunity, and pregnancy. Their significance in ANCA vasculitis (AAV) ... -
Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4.
Lavelle, Edward; Moran, Barry; Mc Loughlin, Rachel (2010)Pneumolysin (PLY) is a key Streptococcus pneumoniae virulence factor and potential candidate for inclusion in pneumococcal subunit vaccines. Dendritic cells (DC) play a key role in the initiation and instruction of adaptive ... -
A population of proinflammatory T cells coexpresses αβ and γο T cell receptors in mice and humans
Mills, Kingston; Moran, Barry; Hokamp, Karsten (2020)T cells are classically recognized as distinct subsets that express αβ or γδ TCRs. We identify a novel population of T cells that coexpress αβ and γδ TCRs in mice and humans. These hybrid αβ-γδ T cells arose in the murine ...