Browsing by Author "O'DONNELL, JAMES"
Now showing items 1-6 of 6
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Dissociation of activated protein C functions by elimination of protein S cofactor enhancement.
PRESTON, ROGER; O'DONNELL, JAMES; JOHNSON, JENNIFER; HARMON, SHONA; NI AINLE, FIONNUALA (2008)Activated protein C (APC) plays a critical anticoagulant role in vivo by inactivating procoagulant factor Va and factor VIIIa and thus down-regulating thrombin generation. In addition, APC bound to the endothelial cell ... -
Increased endothelial activation in recently symptomatic versus asymptomatic carotid artery stenosis and in cerebral microembolic-signal-negative patient subgroups.
O'DONNELL, JAMES; O'NEILL, DESMOND; COUGHLAN, TARA; MCCABE, DOMINICK; DOHERTY, COLIN; HARBISON, JOSEPH; COLGAN, MARY (2014)von Willebrand factor propeptide (VWF:Ag II) is potentially a more sensitive marker of acute endothelial activation than von Willebrand factor antigen (VWF:Ag). These biomarkers have not been simultaneously assessed in ... -
Long-term activation of the pro-coagulant response after neoadjuvant chemoradiation and major cancer surgery.
PIDGEON, GRAHAM; REYNOLDS, JOHN; MAHER, STEPHEN; WHITE, BARRY; O'DONNELL, JAMES (2010)Background: The association between cancer, major surgery and venous thromboembolism (VTE) is well established. Multimodal therapy is increasingly being used as standard treatment for localised gastrointestinal ... -
Platelet factor 4 impairs the anticoagulant activity of activated protein C.
PRESTON, ROGER; HARMON, SHONA; NI AINLE, FIONNUALA; O'DONNELL, JAMES; JOHNSON, JENNIFER (2009)Platelet factor 4 (PF4) is an abundant platelet -granule chemokine released following platelet activation. PF4 interacts with thrombomodulin and the -carboxyglutamic acid (Gla) domain of protein C, thereby enhancing ... -
Quantification of unfractionated heparin in human plasma and whole blood by means of novel fluorogenic anti-FXa assays
O'DONNELL, JAMES (Elsevier, 2011)Novel and sensitive plate-based fluorogenic anti-factor Xa (FXa) assays were investigated to quantify unfractionated heparin (UFH) in human plasma and whole blood within the therapeutic ranges of 0-1.6 U/mL and 0?0.8 U/mL, ... -
Severe Plasmodium falciparum malaria is associated with circulating ultra-large von Willebrand multimers and ADAMTS13 inhibition.
PRESTON, ROGER; O'DONNELL, JAMES; JENKINS, P (2009)Plasmodium falciparum infection results in adhesion of infected erythrocytes to blood vessel endothelium, and acute endothelial cell activation, together with sequestration of platelets and leucocytes. We have previously ...