Browsing by Author "O'Sullivan, Jacintha"
Now showing items 1-17 of 17
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1,4-dihydroxy quininib attenuates growth of colorectal cancer cells and xenografts and regulates the TIE-2 signaling pathway in patient tumours
O'Sullivan, Jacintha (2019)Colorectal cancer (CRC) is the second leading cause of cancer associated deaths in developed countries. Cancer progression and metastatic spread is reliant on new blood vasculature, or angiogenesis. Tumour-related angiogenesis ... -
Altered mitochondrial function and energy metabolism is associated with a radioresistant phenotype in oesophageal adenocarcinoma.
Reynolds, John; O'Sullivan, Jacintha; Lynam-Lennon, Niamh (2014)Neoadjuvant chemoradiation therapy (CRT) is increasingly the standard of care for locally advanced oesophageal cancer. A complete pathological response to CRT is associated with a favourable outcome. Radiation therapy is ... -
Bile acids modulate the Golgi membrane fission process via a protein kinase Ceta and protein kinase D-dependent pathway in colonic epithelial cells.
Long, Aideen; Kelleher, Dermot; Byrne, Anne-Marie; Foran, Eilis; Sharma, Ruchika; Davies, Antony; Mahon, Ciara; O'Sullivan, Jacintha; O'Donoghue, Diarmuid (2010)Deoxycholic acid (DCA) is a secondary bile acid that modulates signalling pathways in epithelial cells. DCA has been implicated in pathogenesis of colon carcinoma, particularly by activation of the protein kinase C (PKC) ... -
Changes in mitochondrial stability during the progression of the Barrett's esophagus disease sequence
Ravi, Narayanasamy; Reynolds, John; O'Sullivan, Jacintha; Lynam-Lennon, Niamh; Phelan, James (2016)Background Barrett’s esophagus follows the classic step-wise progression of metaplasia-dysplasia-adenocarcinoma. While Barrett’s esophagus is a leading known risk factor for esophageal adenocarcinoma, the pathogenesis ... -
Characterizing caspase-1 involvement during esophageal disease progression.
Creagh, Emma; O'Sullivan, Jacintha; Reynolds, John; Ravi, Narayanasamy (2020)Barrett’s esophagus (BE) is an inflammatory condition and a neoplastic precursor to esophageal adenocarcinoma (EAC). Inflammasome signaling, which contributes to acute and chronic inflammation, results in caspase-1 activation ... -
Determinants of short- and long-term survival from colorectal cancer in very elderly patients
O'Sullivan, Jacintha; Kevans, David (2014)PURPOSE: Over 5100 colorectal cancers (CRCs) are diagnosed in the United Kingdom in 85years and older age group per year but little is known of cancer progression in this group. We assessed clinical, pathological and ... -
Effect of cigarette smoke extract on the intestinal microenvironment of ulcerative colitis tissue
Lysaght, Joanne; O'Sullivan, Jacintha (2020)Background and aim: Ulcerative colitis (UC) is an autoimmune disease characterized by inflammation in the gastrointestinal tract. The severity of UC is higher in nonsmokers than smokers; however, the biological mechanisms ... -
Excess visceral adiposity induces alterations in mitochondrial function and energy metabolism in esophageal adenocarcinoma.
O'Sullivan, Jacintha; Pidgeon, Graham; Reynolds, John; Porter, Richard; Lynam-Lennon, Niamh (2014)Background Visceral obesity has a strong association with both the incidence and mortality of esophageal adenocarcinoma (EAC). Alterations in mitochondrial function and energy metabolism is an emerging hallmark of cancer, ... -
Leukaemia inhibitory factor is associated with treatment resistance in oesophageal adenocarcinoma.
Dunne, Margaret; Lynam-Lennon, Niamh; O'Sullivan, Jacintha; Ravi, Narayanasamy (2018)Oesophageal cancer is an aggressive disease with a poor 5 year survival rate of <20% of diagnosed patients. Unfortunately, only 20-30% Oesophageal Adenocarinoma (OAC) patients show a beneficial response to neoadjuvant ... -
Measuring the impact of oesophagectomy on physical functioning and physical activity participation: a prospective study
Bennett, Annemarie; Reynolds, John; Guinan, Emer; Doyle, Suzanne; O'Neill, Linda; Elliott, Jessie; O'Sullivan, Jacintha; Hussey, Juliette (2019)Background: Oesophagectomy remains the only curative intervention for oesophageal cancer, with defined nutritional and health-related quality of life (HR-QOL) consequences. It follows therefore that there is a significant ... -
The Mitochondrial Genes BAK1, FIS1 and SFN are Linked with Alterations in Mitochondrial Membrane Potential in Barrett?s Esophagus
Phelan, James; O'Sullivan, Jacintha (2018)Barrett’s esophagus and esophageal cancer lack prognostic markers that allow the tailoring of personalized medicine and biomarkers with potential to provide insight into treatment response. This study aims to characterize ... -
Mucosal-Associated Invariant T Cells Display Diminished Effector Capacity in Oesophageal Adenocarcinoma
Dunne, Margaret; O'Sullivan, Jacintha; Reynolds, John; Ravi, Narayanasamy; Phelan, James (2019)Oesophageal adenocarcinoma (OAC) is an aggressive malignancy with poor prognosis, and incidence is increasing rapidly in the Western world. Mucosal-associated invariant T (MAIT) cells recognize bacterial metabolites and ... -
Polymorphisms Near TBX5 and GDF7 Are Associated With Increased Risk for Barrett's Esophagus.
O'Sullivan, Jacintha; Reynolds, John; Mc Manus, Ross (2015)Barrett ’ s esophagus (BE) increases the risk of esophageal adenocarcinoma (EAC). We found the risk to be BE has been associated with single nucleotide polymorphisms (SNPs) on chromosome 6p21 (within the HLA region) ... -
Protein Kinase C Beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival
O'Sullivan, Jacintha; Mehigan, Brian; Mc Cormick, Paul; Phelan, James (2016)Despite extensive efforts, cancer therapies directed at the Protein Kinase C (PKC) family of serine/threonine kinases have failed in clinical trials. These therapies have been directed at inhibiting PKC and have, in some ... -
Real-time metabolic profiling of oesophageal tumours reveals an altered metabolic phenotype to different oxygen tensions and to treatment with Pyrazinib
Dunne, Margaret; Lysaght, Joanne; Reynolds, John; O'Sullivan, Jacintha; Ravi, Narayanasamy (2020)Oesophageal cancer is the 6th most common cause of cancer related death worldwide. The current standard of care for oesophageal adenocarcinoma (OAC) focuses on neoadjuvant therapy with chemoradiation or chemotherapy, however ... -
The role of inflammation in cancer of the esophagus.
Lysaght, Joanne; Reynolds, John; O'Sullivan, Jacintha; Phelan, James (2014)Esophageal adenocarcinoma is the eighth most common malignancy worldwide. The overall prognosis is poor, with 5-year survival ranges of approximately 15-25%, and 30-50% for patients who can be treated with curative intent. ... -
Tumour vasculature immaturity, oxidative damage and systemic inflammation stratify survival of colorectal cancer patients on bevacizumab treatment
O'Sullivan, Jacintha (2018)Despite treatment of patients with metastatic colorectal cancer (mCRC) with bevacizumab plus chemotherapy, response rates are modest and there are no biomarkers available that will predict response. The aim of this study ...