Browsing by Author "O'Toole, Sharon"
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Circulating tumour cells: The Good, the Bad and the Ugly.
Ward, Mark; O'Toole, Sharon; O'Leary, John; Malone, Victoria; O'Connor, R?is?n (2023)This review is an overview of the current knowledge regarding circulating tumour cells (CTCs), which are potentially the most lethal type of cancer cell, and may be a key component of the metastatic cascade. The clinical ... -
Influenza A virus causes maternal and fetal pathology via innate and adaptive vascular inflammation in mice.
O'Toole, Sharon; O'Neill, Luke; Martin, Cara (2020)Influenza A virus (IAV) infection during pregnancy causes severe maternal and perinatal complications, despite a lack of vertical transmission of IAV across the placenta. Here, we demonstrate a significant alteration in ... -
Pre-Treatment of Platinum Resistant Ovarian Cancer Cells with an MMP-9/MMP-2 Inhibitor Prior to Cisplatin Enhances Cytotoxicity as Determined by High Content Screening.
Norris, Lucy; Martin, Cara; O'Leary, John; Finn, Stephen; O'Toole, Sharon; Sheils, Orla; Abu Saadeh, Feras; Flavin, Richard; Kelly, Lynne (2013)Platinum resistance is a major cause of treatment failure in ovarian cancer. We previously identified matrix metalloproteinase 9 (MMP-9) as a potential therapeutic target of chemoresistant disease. A2780cis (cisplatin-resistant) ... -
Suppression of Natural Killer cell NKG2D and CD226 anti-tumour cascades by platelet cloaked cancer cells: Implications for the metastatic cascade
Gardiner, Clair; O'Toole, Sharon; Sheils, Orla (2019)Tumour cell immune evasion is a principal hallmark of successful metastasis. Tumour cells in the vasculature adopt a platelet cloak that efficiently suppresses the innate immune system by directly inhibiting Natural Killer ...