Browsing by Author "PALSSON, EVA"
Now showing items 1-5 of 5
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Divergent roles for Ras and Rap in the activation of p38 mitogen-activated protein kinase by interleukin-1
O'NEILL, LUKE ANTHONY JOHN; PALSSON, EVA (The American Society for Biochemistry and Molecular Biology, 2000)We have found that lethal toxin from Clostridium sordellii, which specifically inactivates the low molecular weight G proteins Ras, Rap, and Rac, inhibits the activation of p38 mitogen-activated protein kinase (MAPK) by ... -
MyD88 adaptor-like (Mal) functions in the epithelial barrier and contributes to intestinal integrity via protein kinase C
CORR, SINEAD; O'NEILL, LUKE; PALSSON, EVA; FALLON, PADRAIC (2014)The prognosis of epithelial ovarian cancer is poor in part due to the high frequency of chemoresistance. Recent evidence points to the Toll-like receptor-4 (TLR4), and particularly its adaptor protein MyD88, as one potential ... -
Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4
O'NEILL, LUKE ANTHONY JOHN; PALSSON, EVA (British Society for Immunology, 2004)An understanding of lipopolysaccharide (LPS) signal transduction is a key goal in the effort to provide a molecular basis for the lethal effect of LPS during septic shock and point the way to novel therapies. Rapid progress ... -
Succinate is an inflammatory signal that induces IL-1 beta through HIF-1 alpha
MCGETTRICK-DILLON, ANNE; CORR, SINEAD; PALSSON, EVA; KELLY, VINCENT; O'NEILL, LUKE (2013)Macrophages activated by the Gram-negative bacterial product lipopolysaccharide switch their core metabolism from oxidative phosphorylation to glycolysis. Here we show that inhibition of glycolysis with 2-deoxyglucose ... -
Trif-related adapter molecule is phosphorylated by protein kinase C epsilon during Toll-like receptor 4 signalling
MCGETTRICK-DILLON, ANNE; O'NEILL, LUKE ANTHONY JOHN; PALSSON, EVA (National Academy of Sciences, 2006)PKC? has been shown to play a key role in the effect of the Gram-negative bacterial product LPS; however, the target for PKC? in LPS signaling is unknown. LPS signaling is mediated by Toll-like receptor 4, which uses four ...