Browsing by Author "Phelan, James"
Now showing items 1-20 of 26
-
Altered mitochondrial function and energy metabolism is associated with a radioresistant phenotype in oesophageal adenocarcinoma
Connon, Stephen; Reynolds, John; Lynam-Lennon, Niamh; Phelan, James; Maher, Stephen (2014)Neoadjuvant chemoradiation therapy (CRT) is increasingly the standard of care for locally advanced oesophageal cancer. A complete pathological response to CRT is associated with a favourable outcome. Radiation therapy is ... -
'Altered Mitochondrial Function and Energy Metabolism Is Associated with a Radioresistant Phenotype in Oesophageal Adenocarcinoma'.
Phelan, James (2014)Neoadjuvant chemoradiation therapy (CRT) is increasingly the standard of care for locally advanced oesophageal cancer. A complete pathological response to CRT is associated with a favourable outcome. Radiation therapy is ... -
Changes in mitochondrial stability during the progression of the Barrett's esophagus disease sequence
Ravi, Narayanasamy; Reynolds, John; O'Sullivan, Jacintha; Lynam-Lennon, Niamh; Phelan, James (2016)Background Barrett’s esophagus follows the classic step-wise progression of metaplasia-dysplasia-adenocarcinoma. While Barrett’s esophagus is a leading known risk factor for esophageal adenocarcinoma, the pathogenesis ... -
?Changes in mitochondrial stability during the progression of the Barrett?s esophagus sequence?.
Phelan, James (2016)Background: Barrett’s esophagus follows the classic step-wise progression of metaplasia-dysplasia-adenocarcinoma. While Barrett’s esophagus is a leading known risk factor for esophageal adenocarcinoma, the pathogenesis of ... -
Characterising the prognostic potential of HLA-DR during colorectal cancer development
Phelan, James; Dunne, Margaret (2020)HLA-DR, an MHC class II molecule that mediates antigen presentation, is a favourable prognostic indicator in colorectal cancer (CRC). However, the dynamics and location of HLA-DR expression during CRC development are ... -
Desferrioxamine supports metabolic function in primary human macrophages infected with Mycobacterium tuberculosis
Phelan, James; Keane, Joseph; Basdeo, Sharee; O'Sullivan, Mary; O'Neill, Luke (2020)Tuberculosis is the single biggest infectious killer in the world and presents a major global health challenge. Antimicrobial therapy requires many months of multiple drugs and incidences of drug resistant tuberculosis ... -
Differential expression of mitochondrial energy metabolism profiles across the metaplasia-dysplasia-adenocarcinoma disease sequence in Barrett?s oesophagus?.
Phelan, James (2014)Contemporary clinical management of Barrett's oesophagus has highlighted the lack of accurate predictive markers of disease progression to oesophageal cancer. This study aims to examine alterations in mitochondrial energy ... -
Differential expression profiles of oxidative stress levels, 8-oxo-dG and 4-HNE, in Barrett?s esophagus compared to esophageal adenocarcinoma
Phelan, James; Reynolds, John; Ravi, Narayanasamy (2019)Barrett’s esophagus (BE), a chronic inflammatory condition, is the leading risk factor for esophageal adenocarcinoma (EAC). In inflammation to cancer pathways, oxidative stress profiles have been linked to cancer progression. ... -
?Dysregulated bioenergetics: a key regulator of joint inflammation?.
Phelan, James (2016)Objectives: This study examines the relationship between synovial hypoxia and cellular bioenergetics with synovial inflammation. Methods: Primary rheumatoid arthritis synovial fibroblasts (RASF) were cultured with ... -
The Effect of Tuberculosis Antimicrobials on the Immunometabolic Profiles of Primary Human Macrophages Stimulated with Mycobacterium tuberculosis
Phelan, James (2021)Tuberculosis (TB) remains a global health challenge. Patients with drug-sensitive and drug-resistant TB undergo long, arduous, and complex treatment regimens, often involving multiple antimicrobials. While these drugs were ... -
?Examining the connectivity between different cellular processes in the Barrett tissue microenvironment: energy metabolism, hypoxia, inflammation, p53 and obesity?.
Phelan, James (2016)In Barrett associated tumorigenesis, oxidative phosphorylation and glycolysis are reprogrammed early in the disease sequence and act mutually to promote disease progression. However, the link between energy metabolism and ... -
Inhibiting Histone Deacetylases in Human Macrophages Promotes Glycolysis, IL-1β, and T Helper Cell Responses to Mycobacterium tuberculosis
Phelan, James; Keane, Joseph; Basdeo, Sharee (2020)Tuberculosis (TB) is the leading infectious killer in the world. Mycobacterium tuberculosis (Mtb), the bacteria that causes the disease, is phagocytosed by alveolar macrophages (AM) and infiltrating monocyte-derived ... -
Investigation into mitochondrial function and energy metabolism and their connectivity with protumourigenic cellular proceses in Barrett's oesophagus
Phelan, James (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2016)Contemporary clinical management of Barrett’s oesophagus has highlighted the lack of accurate predictors of neoplastic progression. Currently all Barrett’s patients undergo surveillance, however, only a subset of patients ... -
Irish Chemical News
Hobbs, Patrick; Corish, John; Kilcawley, Kieran; Phelan, James; Roche, James J.; Poc, Pavel; Rea, Michael; Maguire, Denise (Institute of Chemistry of IrelandIreland, 2017-08-31)A Message from the President. p6 -- Editorial p8 -- Congress: Food Chemistry p11 -- Inorganic Ireland 2017 p18 -- 69th Irish University Chemistry Research Colloquium 2017 p27 -- Irish Lab Awards 2017 Winners p31 -- The New ... -
The Iron Chelator Desferrioxamine Increases the Efficacy of Bedaquiline in Primary Human Macrophages Infected with BCG
Phelan, James (2021)For over 50 years, patients with drug-sensitive and drug-resistant tuberculosis have undergone long, arduous, and complex treatment processes with several antimicrobials. With the prevalence of drug-resistant strains on ... -
KH-Type Splicing Regulatory Protein Controls Colorectal Cancer Cell Growth and Modulates the Tumor Microenvironment
Phelan, James (2019)KH-type splicing regulatory protein (KHSRP) is a multifunctional nucleic acid binding protein implicated in key aspects of cancer cell biology: inflammation and cell-fate determination. However, the role KHSRP plays in ... -
Linking Circulating Serum Proteins with Clinical Outcomes in Esophageal Adenocarcinoma?An Emerging Role for Chemokines
Dunne, Margaret; Lysaght, Joanne; Reynolds, John; Ravi, Narayanasamy; Phelan, James (2020)Esophageal adenocarcinoma (EAC) is an aggressive cancer with poor prognosis and incidence is increasing rapidly in the Western world. Multi-modal treatment has improved survival outcomes but only for a minority of patients. ... -
The Mitochondrial Genes BAK1, FIS1 and SFN are Linked with Alterations in Mitochondrial Membrane Potential in Barrett?s Esophagus
Phelan, James; O'Sullivan, Jacintha (2018)Barrett’s esophagus and esophageal cancer lack prognostic markers that allow the tailoring of personalized medicine and biomarkers with potential to provide insight into treatment response. This study aims to characterize ... -
Modulating Iron for Metabolic Support of TB Host Defense
Phelan, James; Keane, Joseph; Basdeo, Sharee (2018)Tuberculosis (TB) is the world's biggest infectious disease killer. The increasing prevalence of multidrug-resistant and extensively drug-resistant TB demonstrates that current treatments are inadequate and there is an ... -
Mucosal-Associated Invariant T Cells Display Diminished Effector Capacity in Oesophageal Adenocarcinoma
Dunne, Margaret; O'Sullivan, Jacintha; Reynolds, John; Ravi, Narayanasamy; Phelan, James (2019)Oesophageal adenocarcinoma (OAC) is an aggressive malignancy with poor prognosis, and incidence is increasing rapidly in the Western world. Mucosal-associated invariant T (MAIT) cells recognize bacterial metabolites and ...