Browsing by Author "Phipps, Sinead"
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Alternative therapeutics for oesophageal cancer : novel toxic bile acid derivatives to induce apoptosis and siRNA library screen to identify genes that regulate cell shape
Phipps, Sinead (Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2015)Oesophageal adenocarcinoma (OAC) is the sixth leading cause of cancer-related deaths worldwide, and has proven most challenging for surgeons as less than a third of patients are suitable for surgical resection due to ... -
siRNA Library Screening Identifies a Druggable Immune-Signature Driving Esophageal Adenocarcinoma Cell Growth
Reynolds, John; Long, Aideen; Duggan, Shane P.; Garry, Catherine; Behan, Fiona; Phipps, Sinead; Kudo, Hiromi; Kirca, Murat; Zaheer, Abdul; McGarrigle, Sarah; Goldin, Robert; Kalloger, Steve E.; Schaeffer, David F.; Strid, Jessica; Kelleher, Dermot (2018)This study de fi nes immune-associated factors supportive of esophageal adenocarcinoma cell growth through small interfering RNA screening and pathologic and functional studies. Fostamatinib R788, targeting Janus ...