Browsing by Author "Roche, Edna"
Now showing items 1-11 of 11
-
Altered endotoxin responsiveness in healthy children with Down syndrome.
Roche, Edna; Doherty, Derek; Leahy, Ronan; Molloy, Eleanor; Balfe, Joanne (2018)Background: Down syndrome (DS) is the most common syndromic immunodeficiency with an increased risk of infection, mortality from sepsis, and autoinflammation. Innate immune function is altered in DS and therefore we examined ... -
Attitudes of parents and staff towards medical students on the paediatric wards.
Roche, Edna; Gadelsayed, Montasser; Meehan, Judith (2014)This study investigates attitudes of parents and staff to medical students on paediatric wards in a Dublin teaching hospital. We invited 100 parents of patients and 30 staff involved in the care of children on the paediatric ... -
Body fat distribution in Turner syndrome and the influence of puberty.
Roche, Edna; Gadelsayed, Montasser (2014)Girls with Turner syndrome (TS) may encounter a wide range of problems. We aim to describe the body composition and its relation to the pubertal development, in affected girls. Precocious pubarche has been found to be ... -
Developing a video intervention to improve youth question-asking and provider education during paediatric diabetes clinic encounters: the Promoting Adolescents Communication and Engagement study
Roche, Edna; Coyne, Imelda (2021)Background Research on long-term health conditions indicates that adolescents are not actively involved during their medical visits. Active involvement is essential because this can help adolescents learn how to self-manage ... -
Encouraging adolescents participation during paediatric diabetes clinic visits: Design and development of a question prompt list intervention
Coyne, Imelda; Roche, Edna (2022)Aims: To investigate adolescents’ communication with healthcare providers (HCPs) and co– design a question prompt list as one part of an intervention to increase patient participation and communication at diabetes ... -
Height in Turner syndrome: Does Growth Hormone Therapy Have Impact?
Roche, Edna; Gadelsayed, Montasser (2014)Short stature is a cardinal feature of Turner syndrome. We examined height outcome and its relation to growth hormone therapy in Irish girls with Turner syndrome. In those with Turner syndrome (TS), the adult stature is ... -
The incidence of childhood type 1 diabetes in Irealnd and the National Childhood Diabetes Register.
Roche, Edna (2014)The incidence of Type 1 diabetes (T1D) in childhood and adolescence is increasing globally with few exceptions. To date limited conflicting data has been available regarding diabetes epidemiology in Ireland. We sought to ... -
Increased systemic inflammation in children with Down syndrome
Molloy, Eleanor; Roche, Edna; Leahy, Ronan; Doherty, Derek; Franklin, Orla; Balfe, Joanne; Kelly, Lynne (2020)Children with Down syndrome (DS) develop more infections, have an increased mortality from sepsis and an increased incidence of chronic inflammatory conditions. Cytokine dysregulation may underpin these clinical sequelae ... -
Melatonin as an immunomodulator in children with Down syndrome
Kelly, Lynne; Roche, Edna; Doherty, Derek (2022)Background: Down syndrome (DS) is a disorder characterised by marked immune dysfunction, increased mortality from sepsis, chronic inflammation, increased oxidative stress, sleep disturbance and possibly abnormal endogenous ... -
Turner syndrome awareness of health issues
Roche, Edna; Gadelsayed, Montasser (2014)Turner syndrome (TS) is an important cause of short stature in girls and occurs in approximately 1 in every 2000 live female births. Affected girls may also experience a wide range of problems. We aim to examine the ...