Browsing by Author "SMITH, SINEAD"
Now showing items 1-7 of 7
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Microarray identifies ADAM family members as key responders to TGF-beta1 in alveolar epithelial cells.
SMITH, SINEAD (2006)The molecular mechanisms of Idiopathic Pulmonary Fibrosis (IPF) remain elusive. Transforming Growth Factor beta 1(TGF-β1) is a key effector cytokine in the development of lung fibrosis. We used microarray and computational ... -
microRNA Profiling: An Overview of Current Technologies and Applications
SMITH, SINEAD (Elsevier, 2014) -
Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization.
SMITH, SINEAD (2012)Emerging concepts suggest that the functional phenotype of macrophages is regulated by transcription factors that define alternative activation states. We found that RBP-J, the main nuclear transducer of signaling via Notch ... -
A role for TLR4 in Clostridium difficile infection and the recognition of surface layer proteins.
SMITH, SINEAD; Ryan, Anthony; Lynch, Mark; Amu, Sylvie; Nel, Hendrik J.; McCoy, Claire E.; Dowling, Jennifer K.; Draper, Eve; O'Reilly, Vincent; McCarthy, Ciara; O'Brien, Julie; Ní Eidhin, Déirdre; O'Connell, Mary J.; Keogh, Brian; Morton, Charles O.; Rogers, Thomas R.; Fallon, Padraic G.; O'Neill, Luke; Kelleher, Dermot; Loscher, Christine E. (2011)Clostridium difficile is the etiological agent of antibiotic-associated diarrhoea (AAD) and pseudomembranous colitis in humans. The role of the surface layer proteins (SLPs) in this disease has not yet been fully explored. ... -
Role of Notch signaling in regulating innate immunity and inflammation in health and disease
SMITH, SINEAD (2016)The Notch signaling pathway is conserved from Droso- phila to mammals and is critically involved in develop- mental processes. In the immune system, it has been established that Notch signaling regulates multiple steps ... -
Strategies for the purification of membrane proteins
SMITH, SINEAD (Springer, 2011)Although membrane proteins account for 20–30% of the coding regions of all sequenced genomes and play crucial roles in many fundamental cell processes, there are relatively few membranes with known 3D structure. This is ...