Browsing by Author "Sheridan, Helen"
Now showing items 1-10 of 10
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The antiviral potential of algal-derived macromolecules
Sheridan, Helen; Nagar, Shipra (2021)A diverse range of molecules with anticancer, antiviral, and antibiotic activities has been identified and isolated from algal species. Such metabolites could address unmet clinical needs and be used to fight human diseases. ... -
Bioactive Indanes: Development and validation of an LC-MS/MS bioanalytical method for the determination of PH46A, a new potential anti-inflammatory agent, in dog and rat plasma and its application to a pharmacokinetic study in dog.
Sheridan, Helen; Scalabrino, Gaia A.; Zhang, Tao; Frankish, Neil (2020)A new chemical entity, which is a chiral indane dimer, PH46A, has been developed by our research group. As a clinical candidate. PH46A has recently completed Phase I clinical studies in man. Previously, during its pre-clinical ... -
Bioactive indanes: Proof of concept study for enantioselective synthetic routes to ph46a, a new potential anti-inflammatory agent
Sheridan, Helen; Frankish, Neil (2018) -
Carissa spinarum L.: A Case Study in Ethnobotany and Bioprospecting Research
Sheridan, Helen; Smyth, Ciara (Intech Open, 2022)This study explores ethnobiological and bioprospecting research through the lens of Carissa spinarum L., using it as a case study to examine wider trends in such research. Hunn’s Phasing in Ethnobiology is used as a ... -
Effect of Extraction Methods on Essential Oil Composition: A Case Study of Irish Bog Myrtle -Myrica gale L.
Sheridan, Helen; Nagar, Shipra (2023)Myrica gale is an aromatic peatland shrub that has reported traditional use as an insect repellent. Different extraction methodologies were used in this study to isolate the essential oil of Myrica gale L., including ... -
Exploring the Irish National Folklore ethnography database (Duchas.ie) for open data research on Traditional Medicine use in post-famine Ireland. An early example of Citizen Science
Sheridan, Helen (2020)A rich archive of oral and ethnological literature is housed in the National Folklore Collection, in University College Dublin, Ireland. The Schools’ Manuscript Collection is one body of information that contains a wealth ... -
The indane diastereoisomers, PH2 and PH5: divergence between their effects in delayed-type hypersensitivity models and a model of colitis
Sheridan, Helen; Frankish, Neil (2018) -
Pentacyclic triterpenes modulate farnesoid X receptor expression in colonic epithelial cells: implications for colonic secretory function.
Sheridan, Helen (2022)The nuclear bile acid receptor, farnesoid X receptor (FXR), is an important regulator of intestinal and metabolic function. Previous studies suggest that pentacyclic triterpenes (PCTs), a class of plant-derived bioactive ... -
Quality control of herbal drugs and preparations: The methods of analysis, their relevance and applications
Sheridan, Helen (2021)Medicinal plants have been used for a very long time to improve human health; they are gaining increasing popularity globally as drugs, complementary and alternative medicines, food supplements, cosmetics and, more surprisingly, ... -
Traditional Chinese Medicine: From Aqueous Extracts to Therapeutic Formulae
Sheridan, Helen (IntechOpen, 2019)Traditional Chinese medicine (TCM) is one of the most established systems of medicine in the world. The therapeutic formulae used in TCM are frequently derived from aqueous decoctions of single plants or complex multicomponent ...