Browsing by Author "Stevenson, Nigel"
Now showing items 1-20 of 23
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Advances in anti-viral immune defence: revealing the importance of the IFN JAK/STAT pathway.
Stevenson, Nigel (Springer, 2017)Interferon-alpha (IFN-a) is a potent anti-viral cytokine, critical to the host immune response against viruses. IFN-a is first produced upon viral detection by pathogen recognition receptors. Following its expression, IFN-a ... -
CCL11 blocks IL-4 and GM-CSF signaling in hematopoietic cells and hinders dendritic cell differentiation via suppressor of cytokine signaling expression
Stevenson, Nigel (Wiley, 2009)The chemokine eotaxin/CCL11 is an important mediator of leukocyte migration, but its effect on inflammatory cytokine signaling has not been explored. In this study, we find that CCL11induces suppressor of cytokine signaling ... -
The chemoattractants, IL-8 and formyl-methionyl-leucyl-phenylalanine, regulate granulocyte colony-stimulating factor signaling by inducing suppressor of cytokine signaling-1 expression
Stevenson, Nigel (2004)Suppressors of cytokine signaling (SOCS) are encoded by immediate early genes known to inhibit cytokine responses in a classical feedback loop. SOCS gene expression has been shown to be induced by many cytokines, ... -
Chronic hepatitis C infection blocks the ability of dendritic cells to secrete IFN-α and stimulate T-cell proliferation
Stevenson, Nigel; O'Farrelly, Cliona (2011)Dendritic cells (DCs) are likely to play a key rolein the compromised T-cell function associated with hepatitis C Virus (HCV) infection. However, studies of DC function inHCV-infected patients to date have yielded conflicting ... -
Control of HIV infection by IFN-α: implications for latency and a cure.
Bourke, Nollaig; Stevenson, Nigel (Springer, 2018)Viral infections, including HIV, trigger the production of type I interferons (IFNs), which in turn, activate a signalling cascade that ultimately culminates with the expression of anti-viral proteins. Mounting evidence ... -
The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility
Stevenson, Nigel (Nature Research, 2011)Deubiquitinating enzymes are now emerging as potential therapeutic targets that control many cellular processes, but few have been demonstrated to control cell motility. Here, we show that ubiquitin-specific ... -
The HCV protein, p7, suppresses inflammatory responses to TNF-a via STAT3 and ERK-mediated induction of SOCS3
Stevenson, Nigel (2019)Viruses use a spectrum of immune evasion strategies that enable infection and replication. The acute phase of hepatitis C virus (HCV) infection is characterized by nonspecific and often mild clinical symptoms, suggesting ... -
The hepatitis C virus (HCV) protein, p7, suppresses inflammatory responses to tumor necrosis factor (TNF)-α via signal transducer and activator of transcription (STAT)3 and extracellular signal-regulated kinase (ERK)-mediated induction of suppressor of cytokine signaling (SOCS)3
Stevenson, Nigel; O'Farrelly, Cliona (2019)Viruses use a spectrum of immune evasion strategies that enable infection and replication. The acute phase of hepatitis C virus (HCV) infection is characterized by nonspecific and often mild clinical symptoms, suggesting ... -
Hepatitis C Virus targets the Interferon-? JAK/STAT pathway by promoting proteasomal degradation in immune cells and hepatocytes.
O'Farrelly, Cliona; Long, Aideen; Bourke, Nollaig; Stevenson, Nigel (2013)JAK/STAT signalling is essential for anti-viral immunity, making IFN-α an obvious anti-viral therapeutic. However, many HCV+ patients fail treatment, indicating that the virus blocks successful IFN-α signalling. We found ... -
The high prevalence of asymptomatic SARS-CoV-2 infection reveals the silent spread of COVID-19
Stevenson, Nigel (2021)The COVID-19 pandemic has led to over 92 million cases and 1.9 million deaths worldwide since its outbreak. Public health responses have focused on identifying symptomatic individuals to halt spread. However, evidence ... -
HIV-1 Promotes the Degradation of Components of the Type 1 IFN JAK/STAT Pathway and Blocks Anti-viral ISG Induction
Stevenson, Nigel; O'Farrelly, Cliona (2018) -
Inhibition of the IFN-α JAK/STAT Pathway by MERS-CoV and SARS-CoV-1 Proteins in Human Epithelial Cells
Stevenson, Nigel (2022)Coronaviruses (CoVs) have caused several global outbreaks with relatively high mortality rates, including Middle East Respiratory Syndrome coronavirus (MERS)-CoV, which emerged in 2012, and Severe Acute Respiratory Syndrome ... -
Long term detection and quantification of SARS-CoV-2 RNA in wastewater in Bahrain
Stevenson, Nigel (2022)Wastewater-based epidemiology is a corroborated environmental surveillance tool in the global fight against SARS-CoV-2. The analysis of wastewater for detection of SARS-CoV-2 RNA may assist policymakers to survey a specific ... -
Mechanisms of SOCS3 phosphorylation upon interleukin-6 stimulation: Contributions of Src- and receptor-tyrosine kinases
Stevenson, Nigel (American Society for Biochemistry and Molecular Biology, 2005)The suppressors of cytokine signaling (SOCS) are negative feedback inhibitors of cytokine signal transduction. SOCS3 is a key negative regulator of interleuking-6 (IL-6) signal transduction. Furthermore, SOCS3 was shown ... -
Neutrophils: Need for Standardized Nomenclature
Little, Mark; Kelly, Lynne; Stevenson, Nigel (2021)Neutrophils are the most abundant innate immune cell with critical anti-microbial functions. Since the discovery of granulocytes at the end of the nineteenth century, the cells have been given many names including phagocytes, ... -
A novel anti-viral role for STAT3 in IFN-α signalling responses.
Stevenson, Nigel; Bowie, Andrew; Roberts, Kim; Bourke, Nollaig; O'Farrelly, Cliona (Springer, 2017-05)The cytokine, Interferon (IFN)-α, induces a wide spectrum of anti-viral mediators, via the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway. STAT1 and STAT2 are well characterised ... -
An overview of current knowledge of deadly covs and their interface with innate immunity
Stevenson, Nigel (2021)Coronaviruses are a large family of zoonotic RNA viruses, whose infection can lead to mild or lethal respiratory tract disease. Severe Acute Respiratory Syndrome-Coronavirus-1 (SARS-CoV-1) first emerged in Guangdong, China ... -
Potential Role of Flavivirus NS2B-NS3 Proteases in Viral Pathogenesis and Anti-flavivirus Drug Discovery Employing Animal Cells and Models: A Review
Stevenson, Nigel (2022)Flaviviruses are known to cause a variety of diseases in humans in different parts of the world. There are very limited numbers of antivirals to combat flavivirus infection, and therefore new drug targets must be explored. ... -
Respiratory syncytial virus NS1 protein degrades STAT2 by using the elongin-cullin E3 ligase
Stevenson, Nigel (2007)Respiratory syncytial virus (RSV) infection causes bronchiolitis and pneumonia in infants. RSV has a linear single-stranded RNA genome encoding 11 proteins, 2 of which are nonstructural (NS1 and NS2). RSV specifically down ...